Characterization of large deletion mutants of mycobacterium tuberculosis selected for isoniazid resistance

Catherine Vilchèze, Rajagopalan Saranathan, Brian Weinrick, William R. Jacobs

Research output: Contribution to journalArticlepeer-review

Abstract

Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant Mycobacterium tuberculosis mutants derived from four M. tuberculosis strains. These LGDs had no growth defect in vitro but could be defective in intracellular growth and showed various sensitivities toward oxidative stress despite lacking katG. The LGD regions comprise 74 genes, mostly of unknown function, that may be important for M. tuberculosis intracellular growth and protection against oxidative stress.

Original languageEnglish (US)
Article numbere00792-20
JournalAntimicrobial agents and chemotherapy
Volume64
Issue number9
DOIs
StatePublished - Sep 2020

Keywords

  • Arginine
  • Deletion
  • Isoniazid
  • Resistance

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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