Characterization of human papillomavirus type 120: A novel betapapillomavirus with tropism for multiple anatomical niches

Danielle Bottalico, Zigui Chen, Boštjan J. Kocjan, Katja Seme, Mario Poljak, Robert D. Burk

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Recent studies indicate that human papillomaviruses (HPVs) from the genera Betapapillomavirus and Gammapapillomavirus are abundant in the human oral cavity. We report the cloning and characterization of a 7304 bp HPV120 genome from the oral cavity that is related most closely to HPV23 (L1 ORF, 83.7 % similarity), clustering it in the genus Betapapillomavirus (β-PV). HPV120 contains five early and two late genes, but no E5 ORF. HPV120 was detected from heterogeneous human biological niches, including the oral cavity, eyebrow hairs, anal canal and penile, vulvar and perianal warts. Characterization of the clinical spectrum of HPV120 infections indicates a broader spectrum of epithelial tropism than appreciated previously for HPV types from the genus β-PV.

Original languageEnglish (US)
Pages (from-to)1774-1779
Number of pages6
JournalJournal of General Virology
Volume93
Issue number8
DOIs
StatePublished - Aug 1 2012

ASJC Scopus subject areas

  • Virology

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