Characteristics of people with self-reported stress-precipitated seizures

Michael Privitera, Michael Walters, Ikjae Lee, Emily Polak, Adrienne Fleck, Donna Schwieterman, Sheryl R. Haut

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Stress is the most common patient-reported seizure precipitant. We aimed to determine mood and epilepsy characteristics of people who report stress-precipitated seizures. Methods: Sequential patients at a tertiary epilepsy center were surveyed about stress as a seizure precipitant. We asked whether acute (lasting minutes-hours) or chronic (lasting days-months) stress was a seizure precipitant, whether stress reduction had been tried, and what effect stress reduction had on seizure frequency. We collected information on antiepileptic drugs, history of depression and anxiety disorder, prior or current treatment for depression or anxiety, and scores on the Neurological Disorders Depression Inventory (NDDI-E) and Generalized Anxiety Disorders-7 (GAD-7) instruments, which are administered at every visit in our Epilepsy Center. We also asked whether respondents thought that they could predict their seizures to determine if stress as a seizure precipitant was correlated with seizure self-prediction. Results: Two hundred sixty-six subjects were included: 219 endorsed stress as a seizure precipitant [STRESS (+)] and 47 did not [STRESS (-)]. Among STRESS (+) subjects, 85% endorsed chronic stress as a seizure precipitant, and 68% endorsed acute stress as a seizure precipitant. In STRESS (+) subjects, 57% had used some type of relaxation or stress reduction method (most commonly yoga, exercise and meditation), and, of those who tried, 88% thought that these methods improved seizures. Among STRESS (-) subjects, 25% had tried relaxation or stress reduction, and 71% thought that seizures improved. Although univariate analysis showed multiple associations with stress as a seizure precipitant, in the multivariable logistic regression, only the GAD-7 score was associated with STRESS (+) (OR. =. 1.18 [1.03-1.35], p. =. 0.017). Subjects who reported stress as a seizure precipitant were more likely to report an ability to self-predict seizures (p. <. 0.001). Conclusion: Stress-precipitated seizures are commonly reported by patients, may be associated with either acute stress or chronic stress, and are associated with higher scores on anxiety tests. Patients frequently use stress reduction methods to self-treat and report high success rates. A prospective, randomized trial of stress reduction for seizures is indicated.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalEpilepsy and Behavior
Volume41
DOIs
StatePublished - Dec 1 2014

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Seizures
Anxiety Disorders
Epilepsy
Depression
Anxiety
Yoga
Meditation
Aptitude
Nervous System Diseases
Anticonvulsants
Self Report
Logistic Models

Keywords

  • Anxiety
  • Depression
  • Epilepsy
  • Seizure
  • Stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology
  • Medicine(all)

Cite this

Characteristics of people with self-reported stress-precipitated seizures. / Privitera, Michael; Walters, Michael; Lee, Ikjae; Polak, Emily; Fleck, Adrienne; Schwieterman, Donna; Haut, Sheryl R.

In: Epilepsy and Behavior, Vol. 41, 01.12.2014, p. 74-77.

Research output: Contribution to journalArticle

Privitera, M, Walters, M, Lee, I, Polak, E, Fleck, A, Schwieterman, D & Haut, SR 2014, 'Characteristics of people with self-reported stress-precipitated seizures', Epilepsy and Behavior, vol. 41, pp. 74-77. https://doi.org/10.1016/j.yebeh.2014.09.028
Privitera M, Walters M, Lee I, Polak E, Fleck A, Schwieterman D et al. Characteristics of people with self-reported stress-precipitated seizures. Epilepsy and Behavior. 2014 Dec 1;41:74-77. https://doi.org/10.1016/j.yebeh.2014.09.028
Privitera, Michael ; Walters, Michael ; Lee, Ikjae ; Polak, Emily ; Fleck, Adrienne ; Schwieterman, Donna ; Haut, Sheryl R. / Characteristics of people with self-reported stress-precipitated seizures. In: Epilepsy and Behavior. 2014 ; Vol. 41. pp. 74-77.
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abstract = "Stress is the most common patient-reported seizure precipitant. We aimed to determine mood and epilepsy characteristics of people who report stress-precipitated seizures. Methods: Sequential patients at a tertiary epilepsy center were surveyed about stress as a seizure precipitant. We asked whether acute (lasting minutes-hours) or chronic (lasting days-months) stress was a seizure precipitant, whether stress reduction had been tried, and what effect stress reduction had on seizure frequency. We collected information on antiepileptic drugs, history of depression and anxiety disorder, prior or current treatment for depression or anxiety, and scores on the Neurological Disorders Depression Inventory (NDDI-E) and Generalized Anxiety Disorders-7 (GAD-7) instruments, which are administered at every visit in our Epilepsy Center. We also asked whether respondents thought that they could predict their seizures to determine if stress as a seizure precipitant was correlated with seizure self-prediction. Results: Two hundred sixty-six subjects were included: 219 endorsed stress as a seizure precipitant [STRESS (+)] and 47 did not [STRESS (-)]. Among STRESS (+) subjects, 85{\%} endorsed chronic stress as a seizure precipitant, and 68{\%} endorsed acute stress as a seizure precipitant. In STRESS (+) subjects, 57{\%} had used some type of relaxation or stress reduction method (most commonly yoga, exercise and meditation), and, of those who tried, 88{\%} thought that these methods improved seizures. Among STRESS (-) subjects, 25{\%} had tried relaxation or stress reduction, and 71{\%} thought that seizures improved. Although univariate analysis showed multiple associations with stress as a seizure precipitant, in the multivariable logistic regression, only the GAD-7 score was associated with STRESS (+) (OR. =. 1.18 [1.03-1.35], p. =. 0.017). Subjects who reported stress as a seizure precipitant were more likely to report an ability to self-predict seizures (p. <. 0.001). Conclusion: Stress-precipitated seizures are commonly reported by patients, may be associated with either acute stress or chronic stress, and are associated with higher scores on anxiety tests. Patients frequently use stress reduction methods to self-treat and report high success rates. A prospective, randomized trial of stress reduction for seizures is indicated.",
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AU - Privitera, Michael

AU - Walters, Michael

AU - Lee, Ikjae

AU - Polak, Emily

AU - Fleck, Adrienne

AU - Schwieterman, Donna

AU - Haut, Sheryl R.

PY - 2014/12/1

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N2 - Stress is the most common patient-reported seizure precipitant. We aimed to determine mood and epilepsy characteristics of people who report stress-precipitated seizures. Methods: Sequential patients at a tertiary epilepsy center were surveyed about stress as a seizure precipitant. We asked whether acute (lasting minutes-hours) or chronic (lasting days-months) stress was a seizure precipitant, whether stress reduction had been tried, and what effect stress reduction had on seizure frequency. We collected information on antiepileptic drugs, history of depression and anxiety disorder, prior or current treatment for depression or anxiety, and scores on the Neurological Disorders Depression Inventory (NDDI-E) and Generalized Anxiety Disorders-7 (GAD-7) instruments, which are administered at every visit in our Epilepsy Center. We also asked whether respondents thought that they could predict their seizures to determine if stress as a seizure precipitant was correlated with seizure self-prediction. Results: Two hundred sixty-six subjects were included: 219 endorsed stress as a seizure precipitant [STRESS (+)] and 47 did not [STRESS (-)]. Among STRESS (+) subjects, 85% endorsed chronic stress as a seizure precipitant, and 68% endorsed acute stress as a seizure precipitant. In STRESS (+) subjects, 57% had used some type of relaxation or stress reduction method (most commonly yoga, exercise and meditation), and, of those who tried, 88% thought that these methods improved seizures. Among STRESS (-) subjects, 25% had tried relaxation or stress reduction, and 71% thought that seizures improved. Although univariate analysis showed multiple associations with stress as a seizure precipitant, in the multivariable logistic regression, only the GAD-7 score was associated with STRESS (+) (OR. =. 1.18 [1.03-1.35], p. =. 0.017). Subjects who reported stress as a seizure precipitant were more likely to report an ability to self-predict seizures (p. <. 0.001). Conclusion: Stress-precipitated seizures are commonly reported by patients, may be associated with either acute stress or chronic stress, and are associated with higher scores on anxiety tests. Patients frequently use stress reduction methods to self-treat and report high success rates. A prospective, randomized trial of stress reduction for seizures is indicated.

AB - Stress is the most common patient-reported seizure precipitant. We aimed to determine mood and epilepsy characteristics of people who report stress-precipitated seizures. Methods: Sequential patients at a tertiary epilepsy center were surveyed about stress as a seizure precipitant. We asked whether acute (lasting minutes-hours) or chronic (lasting days-months) stress was a seizure precipitant, whether stress reduction had been tried, and what effect stress reduction had on seizure frequency. We collected information on antiepileptic drugs, history of depression and anxiety disorder, prior or current treatment for depression or anxiety, and scores on the Neurological Disorders Depression Inventory (NDDI-E) and Generalized Anxiety Disorders-7 (GAD-7) instruments, which are administered at every visit in our Epilepsy Center. We also asked whether respondents thought that they could predict their seizures to determine if stress as a seizure precipitant was correlated with seizure self-prediction. Results: Two hundred sixty-six subjects were included: 219 endorsed stress as a seizure precipitant [STRESS (+)] and 47 did not [STRESS (-)]. Among STRESS (+) subjects, 85% endorsed chronic stress as a seizure precipitant, and 68% endorsed acute stress as a seizure precipitant. In STRESS (+) subjects, 57% had used some type of relaxation or stress reduction method (most commonly yoga, exercise and meditation), and, of those who tried, 88% thought that these methods improved seizures. Among STRESS (-) subjects, 25% had tried relaxation or stress reduction, and 71% thought that seizures improved. Although univariate analysis showed multiple associations with stress as a seizure precipitant, in the multivariable logistic regression, only the GAD-7 score was associated with STRESS (+) (OR. =. 1.18 [1.03-1.35], p. =. 0.017). Subjects who reported stress as a seizure precipitant were more likely to report an ability to self-predict seizures (p. <. 0.001). Conclusion: Stress-precipitated seizures are commonly reported by patients, may be associated with either acute stress or chronic stress, and are associated with higher scores on anxiety tests. Patients frequently use stress reduction methods to self-treat and report high success rates. A prospective, randomized trial of stress reduction for seizures is indicated.

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KW - Depression

KW - Epilepsy

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