Characteristics of methadone maintenance treatment patients prescribed opioid analgesics

Matthew C. Glenn, Nancy L. Sohler, Joanna L. Starrels, Jeronimo Maradiaga, John Jost, Julia H. Arnsten, Chinazo O. Cunningham

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Opioid analgesic use and disorders have dramatically increased among the general American population and those receiving methadone maintenance treatment (MMT). Most research among MMT patients focuses on opioid analgesics misuse or disorders; few studies focus on MMT patients prescribed opioid analgesics. We describe demographic, clinical, and substance use characteristics of MMT patients prescribed opioid analgesics and compare them with MMT patients not prescribed opioid analgesics. Methods: We conducted a cross-sectional secondary data analysis using screening interviews from a parent study. From 2012 to 2015, we recruited adults from 3 MMT Bronx clinics. Questionnaire data included patterns of opioid analgesic use, substance use, comorbid illnesses, and demographic characteristics. Our main dependent variable was patients' report of currently taking prescribed opioid analgesics. To compare characteristics between MMT patients prescribed and not prescribed opioid analgesics, we conducted chi-square tests, t tests, and Mann-Whitney U tests. Results: Of 611 MMT patients, most reported chronic pain (62.0%), hepatitis C virus (HCV) infection (52.1%), and current use of illicit substances (64.2%). Of the 29.8% who reported currently taking prescribed opioid analgesics, most misused their opioid analgesics (57.5%). Patients prescribed (versus not prescribed) opioid analgesics were more likely to report human immunodeficiency virus (HIV) infection (adjusted odds ratio [aOR] = 1.6, 95% confidence interval [CI]: 1.1–2.3) and chronic pain (aOR = 7.6, 95% CI: 4.6–12.6). Conclusion: Among MMT patients primarily in 3 Bronx clinics, nearly one third reported taking prescribed opioid analgesics. Compared with patients not prescribed opioid analgesics, those prescribed opioid analgesics were more likely to report chronic pain and HIV infection. However, between these patients, there was no difference in illicit substance use. These findings highlight the complexity of addressing chronic pain in MMT patients.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalSubstance Abuse
DOIs
StateAccepted/In press - May 26 2016

Fingerprint

Methadone
Opioid Analgesics
Chronic Pain
Therapeutics
Virus Diseases
Odds Ratio
Demography
HIV
Confidence Intervals
Chi-Square Distribution
Nonparametric Statistics
Hepacivirus

Keywords

  • HIV
  • methadone
  • opiate substitution therapy
  • opioid analgesics
  • pain
  • substance use

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

Cite this

Characteristics of methadone maintenance treatment patients prescribed opioid analgesics. / Glenn, Matthew C.; Sohler, Nancy L.; Starrels, Joanna L.; Maradiaga, Jeronimo; Jost, John; Arnsten, Julia H.; Cunningham, Chinazo O.

In: Substance Abuse, 26.05.2016, p. 1-5.

Research output: Contribution to journalArticle

@article{3d8b3bf8ddd448c7961466c7a38b67cc,
title = "Characteristics of methadone maintenance treatment patients prescribed opioid analgesics",
abstract = "Background: Opioid analgesic use and disorders have dramatically increased among the general American population and those receiving methadone maintenance treatment (MMT). Most research among MMT patients focuses on opioid analgesics misuse or disorders; few studies focus on MMT patients prescribed opioid analgesics. We describe demographic, clinical, and substance use characteristics of MMT patients prescribed opioid analgesics and compare them with MMT patients not prescribed opioid analgesics. Methods: We conducted a cross-sectional secondary data analysis using screening interviews from a parent study. From 2012 to 2015, we recruited adults from 3 MMT Bronx clinics. Questionnaire data included patterns of opioid analgesic use, substance use, comorbid illnesses, and demographic characteristics. Our main dependent variable was patients' report of currently taking prescribed opioid analgesics. To compare characteristics between MMT patients prescribed and not prescribed opioid analgesics, we conducted chi-square tests, t tests, and Mann-Whitney U tests. Results: Of 611 MMT patients, most reported chronic pain (62.0{\%}), hepatitis C virus (HCV) infection (52.1{\%}), and current use of illicit substances (64.2{\%}). Of the 29.8{\%} who reported currently taking prescribed opioid analgesics, most misused their opioid analgesics (57.5{\%}). Patients prescribed (versus not prescribed) opioid analgesics were more likely to report human immunodeficiency virus (HIV) infection (adjusted odds ratio [aOR] = 1.6, 95{\%} confidence interval [CI]: 1.1–2.3) and chronic pain (aOR = 7.6, 95{\%} CI: 4.6–12.6). Conclusion: Among MMT patients primarily in 3 Bronx clinics, nearly one third reported taking prescribed opioid analgesics. Compared with patients not prescribed opioid analgesics, those prescribed opioid analgesics were more likely to report chronic pain and HIV infection. However, between these patients, there was no difference in illicit substance use. These findings highlight the complexity of addressing chronic pain in MMT patients.",
keywords = "HIV, methadone, opiate substitution therapy, opioid analgesics, pain, substance use",
author = "Glenn, {Matthew C.} and Sohler, {Nancy L.} and Starrels, {Joanna L.} and Jeronimo Maradiaga and John Jost and Arnsten, {Julia H.} and Cunningham, {Chinazo O.}",
year = "2016",
month = "5",
day = "26",
doi = "10.1080/08897077.2015.1135225",
language = "English (US)",
pages = "1--5",
journal = "Substance Abuse",
issn = "0889-7077",
publisher = "Routledge",

}

TY - JOUR

T1 - Characteristics of methadone maintenance treatment patients prescribed opioid analgesics

AU - Glenn, Matthew C.

AU - Sohler, Nancy L.

AU - Starrels, Joanna L.

AU - Maradiaga, Jeronimo

AU - Jost, John

AU - Arnsten, Julia H.

AU - Cunningham, Chinazo O.

PY - 2016/5/26

Y1 - 2016/5/26

N2 - Background: Opioid analgesic use and disorders have dramatically increased among the general American population and those receiving methadone maintenance treatment (MMT). Most research among MMT patients focuses on opioid analgesics misuse or disorders; few studies focus on MMT patients prescribed opioid analgesics. We describe demographic, clinical, and substance use characteristics of MMT patients prescribed opioid analgesics and compare them with MMT patients not prescribed opioid analgesics. Methods: We conducted a cross-sectional secondary data analysis using screening interviews from a parent study. From 2012 to 2015, we recruited adults from 3 MMT Bronx clinics. Questionnaire data included patterns of opioid analgesic use, substance use, comorbid illnesses, and demographic characteristics. Our main dependent variable was patients' report of currently taking prescribed opioid analgesics. To compare characteristics between MMT patients prescribed and not prescribed opioid analgesics, we conducted chi-square tests, t tests, and Mann-Whitney U tests. Results: Of 611 MMT patients, most reported chronic pain (62.0%), hepatitis C virus (HCV) infection (52.1%), and current use of illicit substances (64.2%). Of the 29.8% who reported currently taking prescribed opioid analgesics, most misused their opioid analgesics (57.5%). Patients prescribed (versus not prescribed) opioid analgesics were more likely to report human immunodeficiency virus (HIV) infection (adjusted odds ratio [aOR] = 1.6, 95% confidence interval [CI]: 1.1–2.3) and chronic pain (aOR = 7.6, 95% CI: 4.6–12.6). Conclusion: Among MMT patients primarily in 3 Bronx clinics, nearly one third reported taking prescribed opioid analgesics. Compared with patients not prescribed opioid analgesics, those prescribed opioid analgesics were more likely to report chronic pain and HIV infection. However, between these patients, there was no difference in illicit substance use. These findings highlight the complexity of addressing chronic pain in MMT patients.

AB - Background: Opioid analgesic use and disorders have dramatically increased among the general American population and those receiving methadone maintenance treatment (MMT). Most research among MMT patients focuses on opioid analgesics misuse or disorders; few studies focus on MMT patients prescribed opioid analgesics. We describe demographic, clinical, and substance use characteristics of MMT patients prescribed opioid analgesics and compare them with MMT patients not prescribed opioid analgesics. Methods: We conducted a cross-sectional secondary data analysis using screening interviews from a parent study. From 2012 to 2015, we recruited adults from 3 MMT Bronx clinics. Questionnaire data included patterns of opioid analgesic use, substance use, comorbid illnesses, and demographic characteristics. Our main dependent variable was patients' report of currently taking prescribed opioid analgesics. To compare characteristics between MMT patients prescribed and not prescribed opioid analgesics, we conducted chi-square tests, t tests, and Mann-Whitney U tests. Results: Of 611 MMT patients, most reported chronic pain (62.0%), hepatitis C virus (HCV) infection (52.1%), and current use of illicit substances (64.2%). Of the 29.8% who reported currently taking prescribed opioid analgesics, most misused their opioid analgesics (57.5%). Patients prescribed (versus not prescribed) opioid analgesics were more likely to report human immunodeficiency virus (HIV) infection (adjusted odds ratio [aOR] = 1.6, 95% confidence interval [CI]: 1.1–2.3) and chronic pain (aOR = 7.6, 95% CI: 4.6–12.6). Conclusion: Among MMT patients primarily in 3 Bronx clinics, nearly one third reported taking prescribed opioid analgesics. Compared with patients not prescribed opioid analgesics, those prescribed opioid analgesics were more likely to report chronic pain and HIV infection. However, between these patients, there was no difference in illicit substance use. These findings highlight the complexity of addressing chronic pain in MMT patients.

KW - HIV

KW - methadone

KW - opiate substitution therapy

KW - opioid analgesics

KW - pain

KW - substance use

UR - http://www.scopus.com/inward/record.url?scp=84976319289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976319289&partnerID=8YFLogxK

U2 - 10.1080/08897077.2015.1135225

DO - 10.1080/08897077.2015.1135225

M3 - Article

C2 - 26731299

AN - SCOPUS:84976319289

SP - 1

EP - 5

JO - Substance Abuse

JF - Substance Abuse

SN - 0889-7077

ER -