Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin)

Jeannette M. Beasley, Brett A. Ange, Cheryl A M Anderson, Edgar R. Miller, Janet T. Holbrook, Lawrence J. Appel

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Obestatin, derived from the same gene as the hunger hormone ghrelin, may reduce food intake in animals. The role of obestatin in human physiology is unclear. We evaluated cross-sectional associations between participant characteristics and fasting levels of obestatin as well two other hormones associated with energy balance, ghrelin and leptin. Data are from the baseline visit of the Optimal Macronutrient Intake Trial to Prevent Heart Disease (OMNI-Heart) Trial that enrolled adults with elevated blood pressure (systolic 120-159 mm Hg or a diastolic of 80-99 mm Hg) but who were otherwise healthy. Partial Spearman's correlations and linear regression models estimated the association between age, gender, BMI, physical activity, and smoking with fasting hormones. Obestatin was directly associated with ghrelin (r = 0.45, P < 0.05). On average, overweight (BMI < 25-30) and obese (BMI > 30) individuals had obestatin concentrations that were 12.6 (s.d. 8.8) and 25.4 (s.d. 8.4) pg/ml lower compared to normal weight (BMI 25) individuals, respectively (P for trend = 0.002). Overweight (BMI 25-30) and obese (BMI 30) individuals had ghrelin concentrations that were 161.7 (s.d. 69.6) and 284.7 (s.d. 66.5) pg/ml lower compared to normal weight (BMI 25) individuals, respectively (P for trend < 0.0001). A 5 unit increase in BMI was associated with 41.3% (s.d. 4.3%) (P 0.0001) higher leptin. Obestatin and ghrelin are directly correlated and share the same patterns of association with participant characteristics. Modifiable risk factors for chronic diseases, such as BMI, are associated with fasting levels of leptin, obestatin, and ghrelin.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalObesity
Volume17
Issue number2
DOIs
StatePublished - Feb 6 2009
Externally publishedYes

Fingerprint

Ghrelin
Appetite
Leptin
Fasting
Hormones
Linear Models
Weights and Measures
Hunger
Heart Diseases
Chronic Disease
Eating
Smoking

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Beasley, J. M., Ange, B. A., Anderson, C. A. M., Miller, E. R., Holbrook, J. T., & Appel, L. J. (2009). Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin). Obesity, 17(2), 349-354. https://doi.org/10.1038/oby.2008.551

Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin). / Beasley, Jeannette M.; Ange, Brett A.; Anderson, Cheryl A M; Miller, Edgar R.; Holbrook, Janet T.; Appel, Lawrence J.

In: Obesity, Vol. 17, No. 2, 06.02.2009, p. 349-354.

Research output: Contribution to journalArticle

Beasley, JM, Ange, BA, Anderson, CAM, Miller, ER, Holbrook, JT & Appel, LJ 2009, 'Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin)', Obesity, vol. 17, no. 2, pp. 349-354. https://doi.org/10.1038/oby.2008.551
Beasley JM, Ange BA, Anderson CAM, Miller ER, Holbrook JT, Appel LJ. Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin). Obesity. 2009 Feb 6;17(2):349-354. https://doi.org/10.1038/oby.2008.551
Beasley, Jeannette M. ; Ange, Brett A. ; Anderson, Cheryl A M ; Miller, Edgar R. ; Holbrook, Janet T. ; Appel, Lawrence J. / Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin). In: Obesity. 2009 ; Vol. 17, No. 2. pp. 349-354.
@article{8c1cff71dbf64009a4d908ccaedb7dbd,
title = "Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin)",
abstract = "Obestatin, derived from the same gene as the hunger hormone ghrelin, may reduce food intake in animals. The role of obestatin in human physiology is unclear. We evaluated cross-sectional associations between participant characteristics and fasting levels of obestatin as well two other hormones associated with energy balance, ghrelin and leptin. Data are from the baseline visit of the Optimal Macronutrient Intake Trial to Prevent Heart Disease (OMNI-Heart) Trial that enrolled adults with elevated blood pressure (systolic 120-159 mm Hg or a diastolic of 80-99 mm Hg) but who were otherwise healthy. Partial Spearman's correlations and linear regression models estimated the association between age, gender, BMI, physical activity, and smoking with fasting hormones. Obestatin was directly associated with ghrelin (r = 0.45, P < 0.05). On average, overweight (BMI < 25-30) and obese (BMI > 30) individuals had obestatin concentrations that were 12.6 (s.d. 8.8) and 25.4 (s.d. 8.4) pg/ml lower compared to normal weight (BMI 25) individuals, respectively (P for trend = 0.002). Overweight (BMI 25-30) and obese (BMI 30) individuals had ghrelin concentrations that were 161.7 (s.d. 69.6) and 284.7 (s.d. 66.5) pg/ml lower compared to normal weight (BMI 25) individuals, respectively (P for trend < 0.0001). A 5 unit increase in BMI was associated with 41.3{\%} (s.d. 4.3{\%}) (P 0.0001) higher leptin. Obestatin and ghrelin are directly correlated and share the same patterns of association with participant characteristics. Modifiable risk factors for chronic diseases, such as BMI, are associated with fasting levels of leptin, obestatin, and ghrelin.",
author = "Beasley, {Jeannette M.} and Ange, {Brett A.} and Anderson, {Cheryl A M} and Miller, {Edgar R.} and Holbrook, {Janet T.} and Appel, {Lawrence J.}",
year = "2009",
month = "2",
day = "6",
doi = "10.1038/oby.2008.551",
language = "English (US)",
volume = "17",
pages = "349--354",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin)

AU - Beasley, Jeannette M.

AU - Ange, Brett A.

AU - Anderson, Cheryl A M

AU - Miller, Edgar R.

AU - Holbrook, Janet T.

AU - Appel, Lawrence J.

PY - 2009/2/6

Y1 - 2009/2/6

N2 - Obestatin, derived from the same gene as the hunger hormone ghrelin, may reduce food intake in animals. The role of obestatin in human physiology is unclear. We evaluated cross-sectional associations between participant characteristics and fasting levels of obestatin as well two other hormones associated with energy balance, ghrelin and leptin. Data are from the baseline visit of the Optimal Macronutrient Intake Trial to Prevent Heart Disease (OMNI-Heart) Trial that enrolled adults with elevated blood pressure (systolic 120-159 mm Hg or a diastolic of 80-99 mm Hg) but who were otherwise healthy. Partial Spearman's correlations and linear regression models estimated the association between age, gender, BMI, physical activity, and smoking with fasting hormones. Obestatin was directly associated with ghrelin (r = 0.45, P < 0.05). On average, overweight (BMI < 25-30) and obese (BMI > 30) individuals had obestatin concentrations that were 12.6 (s.d. 8.8) and 25.4 (s.d. 8.4) pg/ml lower compared to normal weight (BMI 25) individuals, respectively (P for trend = 0.002). Overweight (BMI 25-30) and obese (BMI 30) individuals had ghrelin concentrations that were 161.7 (s.d. 69.6) and 284.7 (s.d. 66.5) pg/ml lower compared to normal weight (BMI 25) individuals, respectively (P for trend < 0.0001). A 5 unit increase in BMI was associated with 41.3% (s.d. 4.3%) (P 0.0001) higher leptin. Obestatin and ghrelin are directly correlated and share the same patterns of association with participant characteristics. Modifiable risk factors for chronic diseases, such as BMI, are associated with fasting levels of leptin, obestatin, and ghrelin.

AB - Obestatin, derived from the same gene as the hunger hormone ghrelin, may reduce food intake in animals. The role of obestatin in human physiology is unclear. We evaluated cross-sectional associations between participant characteristics and fasting levels of obestatin as well two other hormones associated with energy balance, ghrelin and leptin. Data are from the baseline visit of the Optimal Macronutrient Intake Trial to Prevent Heart Disease (OMNI-Heart) Trial that enrolled adults with elevated blood pressure (systolic 120-159 mm Hg or a diastolic of 80-99 mm Hg) but who were otherwise healthy. Partial Spearman's correlations and linear regression models estimated the association between age, gender, BMI, physical activity, and smoking with fasting hormones. Obestatin was directly associated with ghrelin (r = 0.45, P < 0.05). On average, overweight (BMI < 25-30) and obese (BMI > 30) individuals had obestatin concentrations that were 12.6 (s.d. 8.8) and 25.4 (s.d. 8.4) pg/ml lower compared to normal weight (BMI 25) individuals, respectively (P for trend = 0.002). Overweight (BMI 25-30) and obese (BMI 30) individuals had ghrelin concentrations that were 161.7 (s.d. 69.6) and 284.7 (s.d. 66.5) pg/ml lower compared to normal weight (BMI 25) individuals, respectively (P for trend < 0.0001). A 5 unit increase in BMI was associated with 41.3% (s.d. 4.3%) (P 0.0001) higher leptin. Obestatin and ghrelin are directly correlated and share the same patterns of association with participant characteristics. Modifiable risk factors for chronic diseases, such as BMI, are associated with fasting levels of leptin, obestatin, and ghrelin.

UR - http://www.scopus.com/inward/record.url?scp=58849136572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849136572&partnerID=8YFLogxK

U2 - 10.1038/oby.2008.551

DO - 10.1038/oby.2008.551

M3 - Article

C2 - 19057526

AN - SCOPUS:58849136572

VL - 17

SP - 349

EP - 354

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 2

ER -