Characteristics and outcomes of patients with multiple myeloma at the uganda cancer institute

Clement D. Okello, Yusuf Mulumba, Abrahams Omoding, Henry Ddungu, Kristen Welch, Cheryl L. Thompson, Andrew J. Cowan, Matthew M. Cooney, Jackson Orem

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: Data on multiple myeloma (MM) in sub-Sahara Africa is scarce. In Uganda, there is a progressively increasing incidence of MM over the years. Methods: We performed a retrospective study on 217 patients with MM at the UCI using purposive sampling method. The objectives of the study were to determine the clinical characteristics, treatment outcomes, 5 year overall survival and predictors of survival of patients with MM at the UCI from 01 January 2008 to 31 December 2012. Results: There were 119 (54.8%) males; the mean(SD) age of the study population at presentation was 59(12.8) years; 183(84.3%) patients presented with bone pain, and 135 (61.9%) had skeletal pathology; 186(85.3%) were HIV negative, and 152(70%) had Durie-Salmon stage III. The median overall survival was 2.5 years, (95% CI, 0.393-0.595); factors significantly associated with worse survival were Durie-Salmon stage III disease, HR=5.9, 95% CI (1.61 - 21.74; P=0.007) and LDH >225 U/L HR=3.3, 95% CI (0.57 - 5.92; P=0.029). Conclusion: Most patients with multiple myeloma at the UCI were diagnosed at a relatively young age, presented with late stage disease and bone pain, and had a shorter survival time. Factors associated with worse survival were Durie-Salmon stage III and LDH >225 U/L.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalAfrican Health Sciences
Volume21
Issue number1
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • Multiple myeloma
  • Uganda cancer institute

ASJC Scopus subject areas

  • Medicine(all)

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