Chapter 6 The Genetics of Autoimmune Thyroid Diseases

Yaron Tomer

doi:10.1016/S1571-5078(07)00206-1

Chapter 6 The Genetics of Autoimmune Thyroid Diseases

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Autoimmune thyroid diseases (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are complex diseases that arise due to interplay between environmental and genetic factors. In the past decade, several AITD susceptibility genes have been identified and characterized, including both immune-regulatory genes and thyroid-specific genes. Some of these susceptibility genes are specific to either GD or HT, while others confer susceptibility to thyroid autoimmunity in general. Recent studies began dissecting the mechanisms by which these new genes predispose to thyroid autoimmunity, and the emerging mechanisms focus on abnormalities of the immunological synapse. In this chapter, we will summarize the recent data on the genes predisposing to AITD and the emerging mechanisms by which they confer susceptibility to disease.

Original language	English (US)
Title of host publication	Endocrine Manifestations of Systemic Autoimmune Diseases
Editors	Sara Walker, Luis Jara
Pages	61-73
Number of pages	13
DOIs	https://doi.org/10.1016/S1571-5078(07)00206-1
State	Published - 2008
Externally published	Yes

Publication series

Name	Handbook of Systemic Autoimmune Diseases
Volume	9
ISSN (Print)	1571-5078

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1571-5078(07)00206-1

Cite this

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abstract = "Autoimmune thyroid diseases (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are complex diseases that arise due to interplay between environmental and genetic factors. In the past decade, several AITD susceptibility genes have been identified and characterized, including both immune-regulatory genes and thyroid-specific genes. Some of these susceptibility genes are specific to either GD or HT, while others confer susceptibility to thyroid autoimmunity in general. Recent studies began dissecting the mechanisms by which these new genes predispose to thyroid autoimmunity, and the emerging mechanisms focus on abnormalities of the immunological synapse. In this chapter, we will summarize the recent data on the genes predisposing to AITD and the emerging mechanisms by which they confer susceptibility to disease.",

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AB - Autoimmune thyroid diseases (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are complex diseases that arise due to interplay between environmental and genetic factors. In the past decade, several AITD susceptibility genes have been identified and characterized, including both immune-regulatory genes and thyroid-specific genes. Some of these susceptibility genes are specific to either GD or HT, while others confer susceptibility to thyroid autoimmunity in general. Recent studies began dissecting the mechanisms by which these new genes predispose to thyroid autoimmunity, and the emerging mechanisms focus on abnormalities of the immunological synapse. In this chapter, we will summarize the recent data on the genes predisposing to AITD and the emerging mechanisms by which they confer susceptibility to disease.

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Chapter 6 The Genetics of Autoimmune Thyroid Diseases

Abstract

Publication series

ASJC Scopus subject areas

UN SDGs

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