Chapter 6 The Genetics of Autoimmune Thyroid Diseases

Research output: Contribution to journalArticle

Abstract

Autoimmune thyroid diseases (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are complex diseases that arise due to interplay between environmental and genetic factors. In the past decade, several AITD susceptibility genes have been identified and characterized, including both immune-regulatory genes and thyroid-specific genes. Some of these susceptibility genes are specific to either GD or HT, while others confer susceptibility to thyroid autoimmunity in general. Recent studies began dissecting the mechanisms by which these new genes predispose to thyroid autoimmunity, and the emerging mechanisms focus on abnormalities of the immunological synapse. In this chapter, we will summarize the recent data on the genes predisposing to AITD and the emerging mechanisms by which they confer susceptibility to disease.

Original languageEnglish (US)
Pages (from-to)61-73
Number of pages13
JournalHandbook of Systemic Autoimmune Diseases
Volume9
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Thyroid Diseases
Autoimmune Diseases
Hashimoto Disease
Thyroid Gland
Genes
Graves Disease
Disease Susceptibility
Autoimmunity
Immunological Synapses
Regulator Genes

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

Cite this

Chapter 6 The Genetics of Autoimmune Thyroid Diseases. / Tomer, Yaron.

In: Handbook of Systemic Autoimmune Diseases, Vol. 9, 2008, p. 61-73.

Research output: Contribution to journalArticle

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