TY - JOUR
T1 - Chapter 4
T2 - Genital tract infections, cervical inflammation, and antioxidant nutrients--assessing their roles as human papillomavirus cofactors.
AU - Castle, Philip E.
AU - Giuliano, Anna R.
PY - 2003
Y1 - 2003
N2 - Cervical infections by approximately 15 human papillomavirus (HPV) types are the necessary cause of cervical cancer and its immediate precursor lesions. However, oncogenic HPV infections are usually benign and usually resolve within 1-2 years. A few of these infections persist and progress to cervical precancer and cancer. A number of cervical factors, such as infection by sexually transmitted pathogens other than HPV, cervical inflammation, and antioxidant nutrients, may influence the natural history of HPV infection along the pathways of persistence and progression or resolution. We examine the possible roles of these HPV cofactors in cervical carcinogenesis and discuss new methodologies that may enable researchers to measure relevant markers of the cervical microenvironment in which these cofactors may be active.
AB - Cervical infections by approximately 15 human papillomavirus (HPV) types are the necessary cause of cervical cancer and its immediate precursor lesions. However, oncogenic HPV infections are usually benign and usually resolve within 1-2 years. A few of these infections persist and progress to cervical precancer and cancer. A number of cervical factors, such as infection by sexually transmitted pathogens other than HPV, cervical inflammation, and antioxidant nutrients, may influence the natural history of HPV infection along the pathways of persistence and progression or resolution. We examine the possible roles of these HPV cofactors in cervical carcinogenesis and discuss new methodologies that may enable researchers to measure relevant markers of the cervical microenvironment in which these cofactors may be active.
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U2 - 10.1093/oxfordjournals.jncimonographs.a003478
DO - 10.1093/oxfordjournals.jncimonographs.a003478
M3 - Review article
C2 - 12807942
AN - SCOPUS:0142093716
SN - 1052-6773
SP - 29
EP - 34
JO - Journal of the National Cancer Institute. Monographs
JF - Journal of the National Cancer Institute. Monographs
IS - 31
ER -