Chapter 10 The Primary Cilium Coordinates Signaling Pathways in Cell Cycle Control and Migration During Development and Tissue Repair

Søren T. Christensen, Stine F. Pedersen, Peter Satir, Iben R. Veland, Linda Schneider

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRα). We also consider how the primary cilium and the centrosome interact with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration.

Original languageEnglish (US)
Pages (from-to)261-301
Number of pages41
JournalCurrent Topics in Developmental Biology
Volume85
DOIs
StatePublished - 2008

Fingerprint

Cilia
Cell Cycle Checkpoints
Cell Movement
Centrosome
Platelet-Derived Growth Factor alpha Receptor
Extracellular Matrix
Maintenance
Health

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Cite this

Chapter 10 The Primary Cilium Coordinates Signaling Pathways in Cell Cycle Control and Migration During Development and Tissue Repair. / Christensen, Søren T.; Pedersen, Stine F.; Satir, Peter; Veland, Iben R.; Schneider, Linda.

In: Current Topics in Developmental Biology, Vol. 85, 2008, p. 261-301.

Research output: Contribution to journalArticle

Christensen, Søren T. ; Pedersen, Stine F. ; Satir, Peter ; Veland, Iben R. ; Schneider, Linda. / Chapter 10 The Primary Cilium Coordinates Signaling Pathways in Cell Cycle Control and Migration During Development and Tissue Repair. In: Current Topics in Developmental Biology. 2008 ; Vol. 85. pp. 261-301.
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