Chapter 10 The Primary Cilium Coordinates Signaling Pathways in Cell Cycle Control and Migration During Development and Tissue Repair

Søren T. Christensen, Stine F. Pedersen, Peter Satir, Iben R. Veland, Linda Schneider

Research output: Chapter in Book/Report/Conference proceedingChapter

100 Scopus citations

Abstract

Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRα). We also consider how the primary cilium and the centrosome interact with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration.

Original languageEnglish (US)
Title of host publicationCiliary Function in Mammalian Development
EditorsBradley Yoder
Pages261-301
Number of pages41
DOIs
StatePublished - Dec 1 2008

Publication series

NameCurrent Topics in Developmental Biology
Volume85
ISSN (Print)0070-2153

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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    Christensen, S. T., Pedersen, S. F., Satir, P., Veland, I. R., & Schneider, L. (2008). Chapter 10 The Primary Cilium Coordinates Signaling Pathways in Cell Cycle Control and Migration During Development and Tissue Repair. In B. Yoder (Ed.), Ciliary Function in Mammalian Development (pp. 261-301). (Current Topics in Developmental Biology; Vol. 85). https://doi.org/10.1016/S0070-2153(08)00810-7