TY - JOUR
T1 - Chaperone-mediated autophagy
T2 - Selectivity pays off
AU - Cuervo, Ana Maria
N1 - Funding Information:
I thank my numerous colleagues in the field of autophagy who through their animated discussions have helped shape this review. I am in particular debt to Dr. Susmita Kaushik and Ms. Samantha Orenstein for critically reading the manuscript. Work in our laboratory is supported by National Institutes of Health grants from NIA (AG021904, AG031782), NIDKK (DK041918), NINDS (NS038370), a Glenn Foundation Award and a Hirsch/Weill-Caulier Career Scientist Award.
PY - 2010/3
Y1 - 2010/3
N2 - Degradation of intracellular components in lysosomes, generically known as autophagy, can occur through different pathways. This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic pathways owing to its selectivity and distinctive mechanism by which substrates reach the lysosomal lumen. CMA participates in quality control and provides energy to cells under persistently poor nutritional conditions. Alterations in CMA have recently been shown to underlie some severe human disorders for which the decline with age in the activity of this pathway might become a major aggravating factor. Prevention of the age-dependent decline in CMA has major beneficial effects on cellular and organ homeostasis and function, revealing that CMA is an essential component of the anti-aging fight.
AB - Degradation of intracellular components in lysosomes, generically known as autophagy, can occur through different pathways. This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic pathways owing to its selectivity and distinctive mechanism by which substrates reach the lysosomal lumen. CMA participates in quality control and provides energy to cells under persistently poor nutritional conditions. Alterations in CMA have recently been shown to underlie some severe human disorders for which the decline with age in the activity of this pathway might become a major aggravating factor. Prevention of the age-dependent decline in CMA has major beneficial effects on cellular and organ homeostasis and function, revealing that CMA is an essential component of the anti-aging fight.
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U2 - 10.1016/j.tem.2009.10.003
DO - 10.1016/j.tem.2009.10.003
M3 - Review article
C2 - 19857975
AN - SCOPUS:77949328788
SN - 1043-2760
VL - 21
SP - 142
EP - 150
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 3
ER -
