Chaperone-mediated autophagy in protein quality control

Research output: Contribution to journalReview article

180 Scopus citations

Abstract

Chaperone-mediated autophagy is a selective mechanism for degradation of soluble cytosolic proteins in lysosomes that distinguishes itself from other autophagic pathways by the selectivity with which CMA substrates are targeted for degradation. The recent molecular dissection of this autophagic pathway and the development of experimental models with compromised CMA have unveiled the important contribution of this pathway to protein quality control. In fact, CMA activation seems to be a common mechanism of cellular defense against proteotoxicity.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume23
Issue number2
DOIs
StatePublished - Apr 1 2011

ASJC Scopus subject areas

  • Cell Biology

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