Chaperone-mediated autophagy in health and disease

Maria Kon, Ana Maria Cuervo

Research output: Contribution to journalReview article

84 Scopus citations

Abstract

Chaperone-mediated autophagy (CMA) is a lysosomal pathway that participates in the degradation of cytosolic proteins. CMA is activated by starvation and in response to stressors that result in protein damage. The selectivity intrinsic to CMA allows for removal of damaged proteins without disturbing nearby functional ones. CMA works in a coordinated manner with other autophagic pathways, which can compensate for each other. Interest in CMA has recently grown because of the connections established between this autophagic pathway and human pathologies. Here we review the unique properties of CMA compared to other autophagic pathways and its relevance in health and disease.

Original languageEnglish (US)
Pages (from-to)1399-1404
Number of pages6
JournalFEBS Letters
Volume584
Issue number7
DOIs
StatePublished - Apr 1 2010

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Keywords

  • Aging
  • Cellular stress
  • Chaperone
  • Lysosome
  • Protease
  • Protein translocation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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