Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

A little over 1 year ago, we lost a bright scientist and a dear colleague who, in his younger years, proposed the 'heretical' idea that lysosomes could selectively degrade cytosolic proteins. That scientist was J. Fred Dice, and his lifetime's discovery was the degradative pathway that we now know as chaperone-mediated autophagy.

Original languageEnglish (US)
Pages (from-to)535-541
Number of pages7
JournalNature Reviews Molecular Cell Biology
Volume12
Issue number8
DOIs
StatePublished - Aug 1 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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