Chaperone-mediated autophagy: Dedicated saviour and unfortunate victim in the neurodegeneration arena

Jaime L. Schneider, Ana Maria Cuervo

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms, are key in the fight against the proteotoxicity that is often associated with severe neurodegenerative diseases. However, in recent years, a new theme has emerged which suggests that components of protein quality-control pathways are often targets of the toxic effects of pathogenic proteins and that their failure to function properly contributes to pathogenesis and disease progression. In the present mini-review, we describe this dual role as 'saviour' and 'victim' in the context of neurodegeneration for chaperone-mediated autophagy, a cellular pathway involved in the selective degradation of cytosolic proteins in lysosomes.

Original languageEnglish (US)
Pages (from-to)1483-1488
Number of pages6
JournalBiochemical Society transactions
Volume41
Issue number6
DOIs
StatePublished - Dec 1 2013

Keywords

  • Aging
  • Autophagy
  • Chaperone
  • Lysosome
  • Neurodegeneration
  • Proteotoxicity

ASJC Scopus subject areas

  • Biochemistry

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