Chaperone-mediated autophagy and endosomal microautophagy: Joint by a chaperone

Kumsal Tekirdag, Ana Maria Cuervo

Research output: Contribution to journalReview article

75 Scopus citations

Abstract

A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage of proteins for degradation by different proteolytic systems, the common characteristic shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino acid motif in the cargo protein for its autophagic targeting. We summarize the current understanding of the molecular machineries behind each of these types of autophagy.

Original languageEnglish (US)
Pages (from-to)5414-5424
Number of pages11
JournalJournal of Biological Chemistry
Volume293
Issue number15
DOIs
StatePublished - Apr 13 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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