TY - JOUR
T1 - Chaperone-mediated autophagy and endosomal microautophagy
T2 - Joint by a chaperone
AU - Tekirdag, Kumsal
AU - Cuervo, Ana Maria
N1 - Funding Information:
This work was supported by National Institutes of Health Grants AG021904, AG031782, AG038072, and AG054108 from NIA, Grant NS100717 from NINDS, Grant DK098408 from NIDDK, Leducq Network Award RA15CVD04, the Rainwaters Foundation, Glen Foundation, and Backus Foundation, and the generous support of Robert and Renee Belfer. This is the fourth article in the Thematic Minireview series “Autophagy.” The authors declare that they have no conflicts of interest with the contents of this article. The con-tent is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
PY - 2018/4/13
Y1 - 2018/4/13
N2 - A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage of proteins for degradation by different proteolytic systems, the common characteristic shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino acid motif in the cargo protein for its autophagic targeting. We summarize the current understanding of the molecular machineries behind each of these types of autophagy.
AB - A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage of proteins for degradation by different proteolytic systems, the common characteristic shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino acid motif in the cargo protein for its autophagic targeting. We summarize the current understanding of the molecular machineries behind each of these types of autophagy.
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U2 - 10.1074/jbc.R117.818237
DO - 10.1074/jbc.R117.818237
M3 - Review article
C2 - 29247007
AN - SCOPUS:85045335904
VL - 293
SP - 5414
EP - 5424
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 15
ER -