Abstract
A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage of proteins for degradation by different proteolytic systems, the common characteristic shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino acid motif in the cargo protein for its autophagic targeting. We summarize the current understanding of the molecular machineries behind each of these types of autophagy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5414-5424 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 293 |
| Issue number | 15 |
| DOIs | |
| State | Published - Jan 1 2018 |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
Cite this
Chaperone-mediated autophagy and endosomal microautophagy : Joint by a chaperone. / Tekirdag, Kumsal; Cuervo, Ana Maria.
In: Journal of Biological Chemistry, Vol. 293, No. 15, 01.01.2018, p. 5414-5424.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Chaperone-mediated autophagy and endosomal microautophagy
T2 - Joint by a chaperone
AU - Tekirdag, Kumsal
AU - Cuervo, Ana Maria
PY - 2018/1/1
Y1 - 2018/1/1
N2 - A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage of proteins for degradation by different proteolytic systems, the common characteristic shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino acid motif in the cargo protein for its autophagic targeting. We summarize the current understanding of the molecular machineries behind each of these types of autophagy.
AB - A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage of proteins for degradation by different proteolytic systems, the common characteristic shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino acid motif in the cargo protein for its autophagic targeting. We summarize the current understanding of the molecular machineries behind each of these types of autophagy.
UR - http://www.scopus.com/inward/record.url?scp=85045335904&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045335904&partnerID=8YFLogxK
U2 - 10.1074/jbc.R117.818237
DO - 10.1074/jbc.R117.818237
M3 - Review article
VL - 293
SP - 5414
EP - 5424
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 15
ER -