Chaperone-mediated autophagy: A unique way to enter the lysosome world

Research output: Contribution to journalReview article

426 Scopus citations

Abstract

All cellular proteins undergo continuous synthesis and degradation. This permanent renewal is necessary to maintain a functional proteome and to allow rapid changes in levels of specific proteins with regulatory purposes. Although for a long time lysosomes were considered unable to contribute to the selective degradation of individual proteins, the discovery of chaperone-mediated autophagy (CMA) changed this notion. Here, we review the characteristics that set CMA apart from other types of lysosomal degradation and the subset of molecules that confer cells the capability to identify individual cytosolic proteins and direct them across the lysosomal membrane for degradation.

Original languageEnglish (US)
Pages (from-to)407-417
Number of pages11
JournalTrends in Cell Biology
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2012

Keywords

  • Aging
  • Cancer
  • Chaperones
  • Lysosomes
  • Membrane proteins
  • Neurodegeneration
  • Protein degradation

ASJC Scopus subject areas

  • Cell Biology

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