Channeling the homocysteine chapel

Nicholas E.S. Sibinga

doi:10.1182/blood-2011-06-361360

Channeling the homocysteine chapel

Nicholas E.S. Sibinga

Medicine

Research output: Contribution to journal › Comment/debate › peer-review

3 Scopus citations

Abstract

Hyperhomocysteinemia (HHcy), a potent risk factor for cardiovascular disease, is associated with impaired endothelium-dependent vasodilation. In this issue of Blood, Cheng et al report that severe HHcy causes oxidation and tyrosine nitration of small and intermediate conductance Ca2+-activated potassium channels, resulting in impaired endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of resistance arterioles.1.

Original language	English (US)
Pages (from-to)	1717-1719
Number of pages	3
Journal	Blood
Volume	118
Issue number	7
DOIs	https://doi.org/10.1182/blood-2011-06-361360
State	Published - Aug 18 2011

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1182/blood-2011-06-361360

Cite this

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title = "Channeling the homocysteine chapel",

abstract = "Hyperhomocysteinemia (HHcy), a potent risk factor for cardiovascular disease, is associated with impaired endothelium-dependent vasodilation. In this issue of Blood, Cheng et al report that severe HHcy causes oxidation and tyrosine nitration of small and intermediate conductance Ca2+-activated potassium channels, resulting in impaired endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of resistance arterioles.1.",

author = "Sibinga, {Nicholas E.S.}",

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doi = "10.1182/blood-2011-06-361360",

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AU - Sibinga, Nicholas E.S.

PY - 2011/8/18

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AB - Hyperhomocysteinemia (HHcy), a potent risk factor for cardiovascular disease, is associated with impaired endothelium-dependent vasodilation. In this issue of Blood, Cheng et al report that severe HHcy causes oxidation and tyrosine nitration of small and intermediate conductance Ca2+-activated potassium channels, resulting in impaired endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of resistance arterioles.1.

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DO - 10.1182/blood-2011-06-361360

M3 - Comment/debate

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JO - Blood

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Channeling the homocysteine chapel

Abstract

ASJC Scopus subject areas

UN SDGs

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