Channeling the homocysteine chapel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hyperhomocysteinemia (HHcy), a potent risk factor for cardiovascular disease, is associated with impaired endothelium-dependent vasodilation. In this issue of Blood, Cheng et al report that severe HHcy causes oxidation and tyrosine nitration of small and intermediate conductance Ca2+-activated potassium channels, resulting in impaired endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of resistance arterioles.1.

Original languageEnglish (US)
Pages (from-to)1717-1719
Number of pages3
JournalBlood
Volume118
Issue number7
DOIs
StatePublished - Aug 18 2011

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Nitration
Hyperhomocysteinemia
Potassium Channels
Homocysteine
Endothelium
Tyrosine
Blood
Oxidation
Vasodilation
Cardiovascular Diseases

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Channeling the homocysteine chapel. / Sibinga, Nicholas E.S.

In: Blood, Vol. 118, No. 7, 18.08.2011, p. 1717-1719.

Research output: Contribution to journalArticle

Sibinga, Nicholas E.S. / Channeling the homocysteine chapel. In: Blood. 2011 ; Vol. 118, No. 7. pp. 1717-1719.
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