Abstract
Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 54-59 |
| Number of pages | 6 |
| Journal | Experimental Cell Research |
| Volume | 186 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1990 |
Fingerprint
ASJC Scopus subject areas
- Cell Biology
Cite this
Changes in the number of mitochondrial genomes during human development. / Heerdt, Barbara G.; Augenlicht, Leonard H.
In: Experimental Cell Research, Vol. 186, No. 1, 1990, p. 54-59.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in the number of mitochondrial genomes during human development
AU - Heerdt, Barbara G.
AU - Augenlicht, Leonard H.
PY - 1990
Y1 - 1990
N2 - Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.
AB - Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.
UR - http://www.scopus.com/inward/record.url?scp=0025189805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025189805&partnerID=8YFLogxK
U2 - 10.1016/0014-4827(90)90209-S
DO - 10.1016/0014-4827(90)90209-S
M3 - Article
VL - 186
SP - 54
EP - 59
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 1
ER -