TY - JOUR
T1 - Changes in the number of mitochondrial genomes during human development
AU - Heerdt, Barbara G.
AU - Augenlicht, Leonard H.
PY - 1990/1
Y1 - 1990/1
N2 - Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.
AB - Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.
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U2 - 10.1016/0014-4827(90)90209-S
DO - 10.1016/0014-4827(90)90209-S
M3 - Article
C2 - 2153553
AN - SCOPUS:0025189805
VL - 186
SP - 54
EP - 59
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 1
ER -