Changes in the number of mitochondrial genomes during human development

Barbara G. Heerdt, Leonard H. Augenlicht

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.

Original languageEnglish (US)
Pages (from-to)54-59
Number of pages6
JournalExperimental Cell Research
Volume186
Issue number1
DOIs
StatePublished - 1990

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Mitochondrial Genome
Human Development
Electron Transport Complex IV
Fetal Development
Mitochondrial DNA
Complementary DNA
DNA

ASJC Scopus subject areas

  • Cell Biology

Cite this

Changes in the number of mitochondrial genomes during human development. / Heerdt, Barbara G.; Augenlicht, Leonard H.

In: Experimental Cell Research, Vol. 186, No. 1, 1990, p. 54-59.

Research output: Contribution to journalArticle

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