Changes in the number of mitochondrial genomes during human development

Barbara G. Heerdt, Leonard H. Augenlicht

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.

Original languageEnglish (US)
Pages (from-to)54-59
Number of pages6
JournalExperimental Cell Research
Volume186
Issue number1
DOIs
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Cell Biology

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