Changes in the number of mitochondrial genomes during human development

Barbara G. Heerdt; Leonard H. Augenlicht

doi:10.1016/0014-4827(90)90209-S

Changes in the number of mitochondrial genomes during human development

Barbara G. Heerdt, Leonard H. Augenlicht

Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.

Original language	English (US)
Pages (from-to)	54-59
Number of pages	6
Journal	Experimental Cell Research
Volume	186
Issue number	1
DOIs	https://doi.org/10.1016/0014-4827(90)90209-S
State	Published - Jan 1990

ASJC Scopus subject areas

Cell Biology

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10.1016/0014-4827(90)90209-S

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title = "Changes in the number of mitochondrial genomes during human development",

abstract = "Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.",

author = "Heerdt, {Barbara G.} and Augenlicht, {Leonard H.}",

note = "Funding Information: i Supported in part by USPHS Grants CA 40558, P30-CA 13330 and a grant from the Aaron Diamond {\textquoteright} To whom reprint requests should be addressed.",

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AU - Heerdt, Barbara G.

AU - Augenlicht, Leonard H.

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PY - 1990/1

Y1 - 1990/1

N2 - Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.

AB - Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.

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Changes in the number of mitochondrial genomes during human development

Abstract

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