TY - JOUR
T1 - Changes in serum electrolytes during treatment of patients in liver failure with molecular adsorbent recirculating system
AU - Doria, Cataldo
AU - Doyle, H. R.
AU - Mandalà, L.
AU - Marino, I. R.
AU - Caruana, G.
AU - Gruttadauria, S.
AU - Lauro, A.
AU - Magnone, M.
AU - Scotti Foglieni, C.
AU - Lamonaca, V.
AU - Scott, V. L.
PY - 2003/10
Y1 - 2003/10
N2 - Purpose: To study the effect of MARS on serum electrolytes during liver failure. Design: Twenty-three patients admitted to a quaternary health care facility from September 2000 to May 2002, 22 adults and 1 child, 11 males (48%) and 12 females (52%), age 15-70 (median 53), treated with MARS for: 12 acute-on-chronic liver failure (52%); 4 fulminant hepatic failure (17%); 3 intractable pruritus (13%); 2 primary-non-function (9%); 2 following major liver resection (9%). Procedures: Sodium, potassium, chloride, phosphorus, calcium, and magnesium were measured in the serum, ultrafiltrate and albumin circuit before and after MARS. Statistical methods: A comparison of electrolyte concentrations, before and after MARS, was performed using a paired t test. Main findings: Serum electrolyte concentrations before and after MARS, while statistically significant in some cases, were very small, and of no clinical relevance. Conclusion: MARS exchanges potassium, chloride, calcium, and magnesium by ultrafiltration; sodium by the albumin dialysis.
AB - Purpose: To study the effect of MARS on serum electrolytes during liver failure. Design: Twenty-three patients admitted to a quaternary health care facility from September 2000 to May 2002, 22 adults and 1 child, 11 males (48%) and 12 females (52%), age 15-70 (median 53), treated with MARS for: 12 acute-on-chronic liver failure (52%); 4 fulminant hepatic failure (17%); 3 intractable pruritus (13%); 2 primary-non-function (9%); 2 following major liver resection (9%). Procedures: Sodium, potassium, chloride, phosphorus, calcium, and magnesium were measured in the serum, ultrafiltrate and albumin circuit before and after MARS. Statistical methods: A comparison of electrolyte concentrations, before and after MARS, was performed using a paired t test. Main findings: Serum electrolyte concentrations before and after MARS, while statistically significant in some cases, were very small, and of no clinical relevance. Conclusion: MARS exchanges potassium, chloride, calcium, and magnesium by ultrafiltration; sodium by the albumin dialysis.
KW - Albumin
KW - Artificial liver
KW - Dialysis
KW - Liver failure
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U2 - 10.1177/039139880302601008
DO - 10.1177/039139880302601008
M3 - Article
C2 - 14636008
AN - SCOPUS:10744221708
SN - 0391-3988
VL - 26
SP - 918
EP - 923
JO - Life Support Systems
JF - Life Support Systems
IS - 10
ER -