Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy

H. R. Mali; S. A. Siddiqui; Madhur Garg; R. K. Singh; M. L.B. Bhatt

doi:10.1007/BF02873441

Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy

H. R. Mali, S. A. Siddiqui, Madhur Garg, R. K. Singh, M. L.B. Bhatt

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Present study reports changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40-70 Gy in 4-7 weeks. SCLs were again estimated in patients following irradiation, the mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.

Original language	English (US)
Pages (from-to)	36-40
Number of pages	5
Journal	Indian Journal of Clinical Biochemistry
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/BF02873441
State	Published - 1998

Keywords

Malignancy
Radiotherapy
Serum copper

ASJC Scopus subject areas

Clinical Biochemistry

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10.1007/BF02873441

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title = "Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy",

abstract = "Present study reports changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40-70 Gy in 4-7 weeks. SCLs were again estimated in patients following irradiation, the mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.",

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AU - Mali, H. R.

AU - Siddiqui, S. A.

AU - Garg, Madhur

AU - Singh, R. K.

AU - Bhatt, M. L.B.

PY - 1998

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N2 - Present study reports changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40-70 Gy in 4-7 weeks. SCLs were again estimated in patients following irradiation, the mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.

AB - Present study reports changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40-70 Gy in 4-7 weeks. SCLs were again estimated in patients following irradiation, the mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.

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