Abstract
Present study reports changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40-70 Gy in 4-7 weeks. SCLs were again estimated in patients following irradiation, the mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 36-40 |
| Number of pages | 5 |
| Journal | Indian Journal of Clinical Biochemistry |
| Volume | 13 |
| Issue number | 1 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Malignancy
- Radiotherapy
- Serum copper
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy. / Mali, H. R.; Siddiqui, S. A.; Garg, Madhur K.; Singh, R. K.; Bhatt, M. L B.
In: Indian Journal of Clinical Biochemistry, Vol. 13, No. 1, 1998, p. 36-40.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy
AU - Mali, H. R.
AU - Siddiqui, S. A.
AU - Garg, Madhur K.
AU - Singh, R. K.
AU - Bhatt, M. L B
PY - 1998
Y1 - 1998
N2 - Present study reports changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40-70 Gy in 4-7 weeks. SCLs were again estimated in patients following irradiation, the mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.
AB - Present study reports changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40-70 Gy in 4-7 weeks. SCLs were again estimated in patients following irradiation, the mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.
KW - Malignancy
KW - Radiotherapy
KW - Serum copper
UR - http://www.scopus.com/inward/record.url?scp=77950096797&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950096797&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:77950096797
VL - 13
SP - 36
EP - 40
JO - Indian Journal of Clinical Biochemistry
JF - Indian Journal of Clinical Biochemistry
SN - 0970-1915
IS - 1
ER -