Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy

H. R. Mali, S. A. Siddiqui, Madhur Garg, R. K. Singh, M. L.B. Bhatt

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Present study reports changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40-70 Gy in 4-7 weeks. SCLs were again estimated in patients following irradiation, the mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalIndian Journal of Clinical Biochemistry
Volume13
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Keywords

  • Malignancy
  • Radiotherapy
  • Serum copper

ASJC Scopus subject areas

  • Clinical Biochemistry

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