Abstract
Previous studies have shown that healthy cigarette smokers have diminished cough reflex sensitivity compared to healthy nonsmokers. We have recently demonstrated that cough reflex sensitivity is enhanced soon after smoking cessation, suggesting that diminished cough sensitivity in smokers results from chronic cigarette smoke-induced desensitization of airway cough receptors. In this study, we evaluated cough reflex sensitivity to capsaicin (C5) in 11 chronic smokers who had discontinued smoking for at least 2 weeks, and then resumed smoking. Two weeks after smoking cessation there was a significant enhancement of cough reflex sensitivity; mean (±SEM) log C5 decreased from 1.77±0.18 to 1.47±0.14 (p=0.01). All subjects resumed smoking after 2-12 weeks of abstinence. Repeat capsaicin cough challenge was performed 14-23 days after resumption of smoking. Mean log C5 increased compared to the last value obtained during the smoking cessation period: 1.42±0.15 vs. 1.77±0.16 (p=0.0004). Mean log C5 after resumption of smoking returned to almost exactly the baseline value. Our findings suggest that the sensitivity of airway cough receptors is a dynamic phenomenon, promptly affected and modulated by changes in environmental conditions, such as the presence or absence of cigarette smoke.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 240-243 |
| Number of pages | 4 |
| Journal | Pulmonary Pharmacology and Therapeutics |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2007 |
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Keywords
- Capsaicin
- Cough
- Nicotine
- Smoking
- Smoking cessation
- Tobacco
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Pharmacology
Cite this
Changes in cough reflex sensitivity after cessation and resumption of cigarette smoking. / Sitkauskiene, Brigita; Stravinskaite, Kristina; Sakalauskas, Raimundas; Dicpinigaitis, Peter Vytautas.
In: Pulmonary Pharmacology and Therapeutics, Vol. 20, No. 3, 06.2007, p. 240-243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in cough reflex sensitivity after cessation and resumption of cigarette smoking
AU - Sitkauskiene, Brigita
AU - Stravinskaite, Kristina
AU - Sakalauskas, Raimundas
AU - Dicpinigaitis, Peter Vytautas
PY - 2007/6
Y1 - 2007/6
N2 - Previous studies have shown that healthy cigarette smokers have diminished cough reflex sensitivity compared to healthy nonsmokers. We have recently demonstrated that cough reflex sensitivity is enhanced soon after smoking cessation, suggesting that diminished cough sensitivity in smokers results from chronic cigarette smoke-induced desensitization of airway cough receptors. In this study, we evaluated cough reflex sensitivity to capsaicin (C5) in 11 chronic smokers who had discontinued smoking for at least 2 weeks, and then resumed smoking. Two weeks after smoking cessation there was a significant enhancement of cough reflex sensitivity; mean (±SEM) log C5 decreased from 1.77±0.18 to 1.47±0.14 (p=0.01). All subjects resumed smoking after 2-12 weeks of abstinence. Repeat capsaicin cough challenge was performed 14-23 days after resumption of smoking. Mean log C5 increased compared to the last value obtained during the smoking cessation period: 1.42±0.15 vs. 1.77±0.16 (p=0.0004). Mean log C5 after resumption of smoking returned to almost exactly the baseline value. Our findings suggest that the sensitivity of airway cough receptors is a dynamic phenomenon, promptly affected and modulated by changes in environmental conditions, such as the presence or absence of cigarette smoke.
AB - Previous studies have shown that healthy cigarette smokers have diminished cough reflex sensitivity compared to healthy nonsmokers. We have recently demonstrated that cough reflex sensitivity is enhanced soon after smoking cessation, suggesting that diminished cough sensitivity in smokers results from chronic cigarette smoke-induced desensitization of airway cough receptors. In this study, we evaluated cough reflex sensitivity to capsaicin (C5) in 11 chronic smokers who had discontinued smoking for at least 2 weeks, and then resumed smoking. Two weeks after smoking cessation there was a significant enhancement of cough reflex sensitivity; mean (±SEM) log C5 decreased from 1.77±0.18 to 1.47±0.14 (p=0.01). All subjects resumed smoking after 2-12 weeks of abstinence. Repeat capsaicin cough challenge was performed 14-23 days after resumption of smoking. Mean log C5 increased compared to the last value obtained during the smoking cessation period: 1.42±0.15 vs. 1.77±0.16 (p=0.0004). Mean log C5 after resumption of smoking returned to almost exactly the baseline value. Our findings suggest that the sensitivity of airway cough receptors is a dynamic phenomenon, promptly affected and modulated by changes in environmental conditions, such as the presence or absence of cigarette smoke.
KW - Capsaicin
KW - Cough
KW - Nicotine
KW - Smoking
KW - Smoking cessation
KW - Tobacco
UR - http://www.scopus.com/inward/record.url?scp=33846929895&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846929895&partnerID=8YFLogxK
U2 - 10.1016/j.pupt.2006.08.005
DO - 10.1016/j.pupt.2006.08.005
M3 - Article
C2 - 17045500
AN - SCOPUS:33846929895
VL - 20
SP - 240
EP - 243
JO - Pulmonary Pharmacology and Therapeutics
JF - Pulmonary Pharmacology and Therapeutics
SN - 1094-5539
IS - 3
ER -