TY - JOUR
T1 - Changes caused by haloperidol are blocked by music in Wistar rat
AU - Tasset, Inmaculada
AU - Quero, Ismael
AU - García-Mayórgaz, Ángel D.
AU - Causse Del Río, Manuel
AU - Túnez, Isaac
AU - Montilla, Pedro
PY - 2012/6
Y1 - 2012/6
N2 - This study sought to evaluate the effect of classical music, using Mozart's sonata for two pianos (K. 448), on changes in dopamine (DA) levels in the striatal nucleus (SN), prefrontal cortex (PFC) and mesencephalon, and on prolactin (PRL) and corticosterone secretion in adult male Wistar rats. Rats were divided into four groups: (1) control, (2) haloperidol treatment (single dose of 2 mg/kg s.c.), (3) music (two 2-h sessions per day) and (4) haloperidol plus music. Rats were sacrificed 2 h after haloperidol injection. Music prompted a fall in plasma PRL and corticosterone levels in healthy rats (P<0.05) and prevented the increase in levels triggered by haloperidol (P<0.001). Moreover, exposure to music was associated with a significant increase in DA levels in all groups, with the increase being particularly marked in PFC and SN (P<0.001). Haloperidol is a recognised D2 receptor antagonist, and these findings suggest that music, by contrast, enhances DA activity and turnover in the brain. The results obtained here bear out reports that music triggers a reduction in systolic pressure and an increase in mesencephalon dopamine levels in human and rats treated with ecstasy, through a calmodulin-dependent system.
AB - This study sought to evaluate the effect of classical music, using Mozart's sonata for two pianos (K. 448), on changes in dopamine (DA) levels in the striatal nucleus (SN), prefrontal cortex (PFC) and mesencephalon, and on prolactin (PRL) and corticosterone secretion in adult male Wistar rats. Rats were divided into four groups: (1) control, (2) haloperidol treatment (single dose of 2 mg/kg s.c.), (3) music (two 2-h sessions per day) and (4) haloperidol plus music. Rats were sacrificed 2 h after haloperidol injection. Music prompted a fall in plasma PRL and corticosterone levels in healthy rats (P<0.05) and prevented the increase in levels triggered by haloperidol (P<0.001). Moreover, exposure to music was associated with a significant increase in DA levels in all groups, with the increase being particularly marked in PFC and SN (P<0.001). Haloperidol is a recognised D2 receptor antagonist, and these findings suggest that music, by contrast, enhances DA activity and turnover in the brain. The results obtained here bear out reports that music triggers a reduction in systolic pressure and an increase in mesencephalon dopamine levels in human and rats treated with ecstasy, through a calmodulin-dependent system.
KW - Corticosterone
KW - Dopaminergic system
KW - Haloperidol
KW - Prolactin
KW - Sonata to piano K. 488
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U2 - 10.1007/s13105-011-0129-8
DO - 10.1007/s13105-011-0129-8
M3 - Article
C2 - 22371013
AN - SCOPUS:84864040598
SN - 1138-7548
VL - 68
SP - 175
EP - 179
JO - Journal of Physiology and Biochemistry
JF - Journal of Physiology and Biochemistry
IS - 2
ER -