Abstract
Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and laboratory-based research to define the pathology resulting from T. cruzi infection has shed light on many of the cellular and molecular mechanisms leading to these manifestations. Antiparasitic treatment may not be appropriate for patients with advanced cardiac disease. Clinical management of Chagas heart disease is similar to that used for cardiomyopathies caused by other processes. Cardiac transplantation has been successfully performed in a small number of patients with Chagas heart disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 53-65 |
| Number of pages | 13 |
| Journal | Cardiology in Review |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2012 |
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Keywords
- benznidazole
- cardiac magnetic resonance imaging
- Chagas disease
- echocardiogram
- heart transplantation
- nifurtimox
- Trypanosoma cruzi
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Chagas heart disease : Report on recent developments. / MacHado, Fabiana S.; Jelicks, Linda A.; Kirchhoff, Louis V.; Shirani, Jamshid; Nagajyothi, Fnu; Mukherjee, Shankar; Nelson, Randin C.; Coyle, Christina M.; Spray, David C.; De Carvalho, Antonio C Campos; Guan, Fangxia; Prado, Cibele M.; Lisanti, Michael P.; Weiss, Louis M.; Montgomery, Susan P.; Tanowitz, Herbert B.
In: Cardiology in Review, Vol. 20, No. 2, 03.2012, p. 53-65.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chagas heart disease
T2 - Report on recent developments
AU - MacHado, Fabiana S.
AU - Jelicks, Linda A.
AU - Kirchhoff, Louis V.
AU - Shirani, Jamshid
AU - Nagajyothi, Fnu
AU - Mukherjee, Shankar
AU - Nelson, Randin C.
AU - Coyle, Christina M.
AU - Spray, David C.
AU - De Carvalho, Antonio C Campos
AU - Guan, Fangxia
AU - Prado, Cibele M.
AU - Lisanti, Michael P.
AU - Weiss, Louis M.
AU - Montgomery, Susan P.
AU - Tanowitz, Herbert B.
PY - 2012/3
Y1 - 2012/3
N2 - Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and laboratory-based research to define the pathology resulting from T. cruzi infection has shed light on many of the cellular and molecular mechanisms leading to these manifestations. Antiparasitic treatment may not be appropriate for patients with advanced cardiac disease. Clinical management of Chagas heart disease is similar to that used for cardiomyopathies caused by other processes. Cardiac transplantation has been successfully performed in a small number of patients with Chagas heart disease.
AB - Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and laboratory-based research to define the pathology resulting from T. cruzi infection has shed light on many of the cellular and molecular mechanisms leading to these manifestations. Antiparasitic treatment may not be appropriate for patients with advanced cardiac disease. Clinical management of Chagas heart disease is similar to that used for cardiomyopathies caused by other processes. Cardiac transplantation has been successfully performed in a small number of patients with Chagas heart disease.
KW - benznidazole
KW - cardiac magnetic resonance imaging
KW - Chagas disease
KW - echocardiogram
KW - heart transplantation
KW - nifurtimox
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=84857373431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857373431&partnerID=8YFLogxK
U2 - 10.1097/CRD.0b013e31823efde2
DO - 10.1097/CRD.0b013e31823efde2
M3 - Article
C2 - 22293860
AN - SCOPUS:84857373431
VL - 20
SP - 53
EP - 65
JO - Cardiology in Review
JF - Cardiology in Review
SN - 1061-5377
IS - 2
ER -