Chagas heart disease: Report on recent developments

Fabiana S. MacHado, Linda A. Jelicks, Louis V. Kirchhoff, Jamshid Shirani, Fnu Nagajyothi, Shankar Mukherjee, Randin C. Nelson, Christina M. Coyle, David C. Spray, Antonio C Campos De Carvalho, Fangxia Guan, Cibele M. Prado, Michael P. Lisanti, Louis M. Weiss, Susan P. Montgomery, Herbert B. Tanowitz

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and laboratory-based research to define the pathology resulting from T. cruzi infection has shed light on many of the cellular and molecular mechanisms leading to these manifestations. Antiparasitic treatment may not be appropriate for patients with advanced cardiac disease. Clinical management of Chagas heart disease is similar to that used for cardiomyopathies caused by other processes. Cardiac transplantation has been successfully performed in a small number of patients with Chagas heart disease.

Original languageEnglish (US)
Pages (from-to)53-65
Number of pages13
JournalCardiology in Review
Volume20
Issue number2
DOIs
StatePublished - Mar 2012

Fingerprint

Chagas Disease
Heart Diseases
Trypanosoma cruzi
Antiparasitic Agents
Latin America
Emigration and Immigration
Dilated Cardiomyopathy
Heart Transplantation
Cardiomyopathies
Cardiac Arrhythmias
Parasites
Heart Failure
Stroke
Pathology
Infection
Research
Therapeutics

Keywords

  • benznidazole
  • cardiac magnetic resonance imaging
  • Chagas disease
  • echocardiogram
  • heart transplantation
  • nifurtimox
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

MacHado, F. S., Jelicks, L. A., Kirchhoff, L. V., Shirani, J., Nagajyothi, F., Mukherjee, S., ... Tanowitz, H. B. (2012). Chagas heart disease: Report on recent developments. Cardiology in Review, 20(2), 53-65. https://doi.org/10.1097/CRD.0b013e31823efde2

Chagas heart disease : Report on recent developments. / MacHado, Fabiana S.; Jelicks, Linda A.; Kirchhoff, Louis V.; Shirani, Jamshid; Nagajyothi, Fnu; Mukherjee, Shankar; Nelson, Randin C.; Coyle, Christina M.; Spray, David C.; De Carvalho, Antonio C Campos; Guan, Fangxia; Prado, Cibele M.; Lisanti, Michael P.; Weiss, Louis M.; Montgomery, Susan P.; Tanowitz, Herbert B.

In: Cardiology in Review, Vol. 20, No. 2, 03.2012, p. 53-65.

Research output: Contribution to journalArticle

MacHado, FS, Jelicks, LA, Kirchhoff, LV, Shirani, J, Nagajyothi, F, Mukherjee, S, Nelson, RC, Coyle, CM, Spray, DC, De Carvalho, ACC, Guan, F, Prado, CM, Lisanti, MP, Weiss, LM, Montgomery, SP & Tanowitz, HB 2012, 'Chagas heart disease: Report on recent developments', Cardiology in Review, vol. 20, no. 2, pp. 53-65. https://doi.org/10.1097/CRD.0b013e31823efde2
MacHado FS, Jelicks LA, Kirchhoff LV, Shirani J, Nagajyothi F, Mukherjee S et al. Chagas heart disease: Report on recent developments. Cardiology in Review. 2012 Mar;20(2):53-65. https://doi.org/10.1097/CRD.0b013e31823efde2
MacHado, Fabiana S. ; Jelicks, Linda A. ; Kirchhoff, Louis V. ; Shirani, Jamshid ; Nagajyothi, Fnu ; Mukherjee, Shankar ; Nelson, Randin C. ; Coyle, Christina M. ; Spray, David C. ; De Carvalho, Antonio C Campos ; Guan, Fangxia ; Prado, Cibele M. ; Lisanti, Michael P. ; Weiss, Louis M. ; Montgomery, Susan P. ; Tanowitz, Herbert B. / Chagas heart disease : Report on recent developments. In: Cardiology in Review. 2012 ; Vol. 20, No. 2. pp. 53-65.
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