Chagas heart disease: Report on recent developments

Fabiana S. MacHado, Linda A. Jelicks, Louis V. Kirchhoff, Jamshid Shirani, Fnu Nagajyothi, Shankar Mukherjee, Randin Nelson, Christina M. Coyle, David C. Spray, Antonio C.Campos De Carvalho, Fangxia Guan, Cibele M. Prado, Michael P. Lisanti, Louis M. Weiss, Susan P. Montgomery, Herbert B. Tanowitz

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and laboratory-based research to define the pathology resulting from T. cruzi infection has shed light on many of the cellular and molecular mechanisms leading to these manifestations. Antiparasitic treatment may not be appropriate for patients with advanced cardiac disease. Clinical management of Chagas heart disease is similar to that used for cardiomyopathies caused by other processes. Cardiac transplantation has been successfully performed in a small number of patients with Chagas heart disease.

Original languageEnglish (US)
Pages (from-to)53-65
Number of pages13
JournalCardiology in review
Volume20
Issue number2
DOIs
StatePublished - Mar 1 2012

Keywords

  • Chagas disease
  • Trypanosoma cruzi
  • benznidazole
  • cardiac magnetic resonance imaging
  • echocardiogram
  • heart transplantation
  • nifurtimox

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    MacHado, F. S., Jelicks, L. A., Kirchhoff, L. V., Shirani, J., Nagajyothi, F., Mukherjee, S., Nelson, R., Coyle, C. M., Spray, D. C., De Carvalho, A. C. C., Guan, F., Prado, C. M., Lisanti, M. P., Weiss, L. M., Montgomery, S. P., & Tanowitz, H. B. (2012). Chagas heart disease: Report on recent developments. Cardiology in review, 20(2), 53-65. https://doi.org/10.1097/CRD.0b013e31823efde2