Chagas' disease: Microvascular and interstitial matrix abnormalities characteristic of congestive cardiomyopathy of diverse etiology

Stephen M. Factor, Murray Wittner, Herbert B. Tanowitz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chagas' disease, due to a chronic and persistent infection with the parasite Trypanosoma cruzi, is the cause of one of the most prevalent forms of congestive cardiomyopathy in South and Central America. In common with other congestive cardiomyopathies due to acquired and hereditary etiologies seen worldwide, chagasic cardiomyopathy is characterized by cardiomegaly, ventricular chamber remodeling, myocellular necrosis, and multifocal areas of interstitial and replacement fibrosis. The microscopic presence of the parasite in the late stages of the disease is rare. This review examines some of the evidence for the role of a dysfunctional microvasculature as a pathophysiological mechanism for myocardial damage in chagasic cardiomyopathy. Perturbations of the interstitial connective tissue matrix in Chagas' disease also are described in regard to the remodeling characteristic of the affected ventricle. Similar abnormalities of the microvasculature and matrix have been reported in other congestive cardiomyopathies, thereby suggesting that common pathophysiologic mechanisms may lead to ventricular damage even when the initiating etiologic agent is different. Preventive treatment or palliation of Chagas' cardiomyopathy and other congestive cardiomyopathies may result from a better understanding of these secondary pathogenetic events.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalCardiovascular Pathology
Volume5
Issue number4
DOIs
StatePublished - Jul 1996
Externally publishedYes

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Chagas Disease
Dilated Cardiomyopathy
Microvessels
Cardiomyopathies
Chagas Cardiomyopathy
Central America
Parasitic Diseases
Ventricular Remodeling
South America
Trypanosoma cruzi
Cardiomegaly
Rare Diseases
Connective Tissue
Parasites
Fibrosis
Necrosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine

Cite this

Chagas' disease : Microvascular and interstitial matrix abnormalities characteristic of congestive cardiomyopathy of diverse etiology. / Factor, Stephen M.; Wittner, Murray; Tanowitz, Herbert B.

In: Cardiovascular Pathology, Vol. 5, No. 4, 07.1996, p. 203-207.

Research output: Contribution to journalArticle

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