Abstract
Little is known about whether cholesteryl ester transfer protein ( CETP ) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between the CETP variant rs3764261 and dietary interventions on changes in lipid levels among 732 overweight/obese adults from a 2 year randomized weight-loss trial [Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST)], and replicated the findings in 171 overweight/obese adults from an independent 2 year weight-loss trial [Dietary Intervention Randomized Controlled Trial (DIRECT)]. In the POUNDS LOST, participants with the CETP rs3764261 CC genotype on the high-fat diet had larger increases in HDL cholesterol (P = 0.001) and decreases in triglycerides (P = 0.007) than those on the low-fat diet at 6 months, while no significant difference between these two diets was observed among participants carrying other genotypes. The gene-diet interactions on changes in HDL-cholesterol and triglycerides were replicated in the DIRECT (pooled P for interaction ≤ 0.01). Similar results on trajectory of changes in HDL cholesterol and triglycerides over the 2 year intervention were observed in both trials. Our study provides replicable evidence that individuals with the CETP rs3764261 CC genotype might derive greater effects on raising HDL cholesterol and lowering triglycerides by choosing a low-carbohydrate/high-fat weight-loss diet instead of a low-fat diet.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 713-721 |
| Number of pages | 9 |
| Journal | Journal of Lipid Research |
| Volume | 56 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2015 |
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Keywords
- Cholesteryl ester transfer protein
- Dietary intervention randomized controlled trial
- Gene-diet interaction
- Preventing overweight using novel dietary strategies
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Endocrinology
Cite this
CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials. / Qi, Qibin; Durst, Ronen; Schwarzfuchs, Dan; Leitersdorf, Eran; Shpitzen, Shoshi; Li, Yanping; Wu, Hongyu; Champagne, Catherine M.; Hu, Frank B.; Stampfer, Meir J.; Bray, George A.; Sacks, Frank M.; Shai, Iris; Qi, Lu.
In: Journal of Lipid Research, Vol. 56, No. 3, 01.03.2015, p. 713-721.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials
AU - Qi, Qibin
AU - Durst, Ronen
AU - Schwarzfuchs, Dan
AU - Leitersdorf, Eran
AU - Shpitzen, Shoshi
AU - Li, Yanping
AU - Wu, Hongyu
AU - Champagne, Catherine M.
AU - Hu, Frank B.
AU - Stampfer, Meir J.
AU - Bray, George A.
AU - Sacks, Frank M.
AU - Shai, Iris
AU - Qi, Lu
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Little is known about whether cholesteryl ester transfer protein ( CETP ) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between the CETP variant rs3764261 and dietary interventions on changes in lipid levels among 732 overweight/obese adults from a 2 year randomized weight-loss trial [Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST)], and replicated the findings in 171 overweight/obese adults from an independent 2 year weight-loss trial [Dietary Intervention Randomized Controlled Trial (DIRECT)]. In the POUNDS LOST, participants with the CETP rs3764261 CC genotype on the high-fat diet had larger increases in HDL cholesterol (P = 0.001) and decreases in triglycerides (P = 0.007) than those on the low-fat diet at 6 months, while no significant difference between these two diets was observed among participants carrying other genotypes. The gene-diet interactions on changes in HDL-cholesterol and triglycerides were replicated in the DIRECT (pooled P for interaction ≤ 0.01). Similar results on trajectory of changes in HDL cholesterol and triglycerides over the 2 year intervention were observed in both trials. Our study provides replicable evidence that individuals with the CETP rs3764261 CC genotype might derive greater effects on raising HDL cholesterol and lowering triglycerides by choosing a low-carbohydrate/high-fat weight-loss diet instead of a low-fat diet.
AB - Little is known about whether cholesteryl ester transfer protein ( CETP ) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between the CETP variant rs3764261 and dietary interventions on changes in lipid levels among 732 overweight/obese adults from a 2 year randomized weight-loss trial [Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST)], and replicated the findings in 171 overweight/obese adults from an independent 2 year weight-loss trial [Dietary Intervention Randomized Controlled Trial (DIRECT)]. In the POUNDS LOST, participants with the CETP rs3764261 CC genotype on the high-fat diet had larger increases in HDL cholesterol (P = 0.001) and decreases in triglycerides (P = 0.007) than those on the low-fat diet at 6 months, while no significant difference between these two diets was observed among participants carrying other genotypes. The gene-diet interactions on changes in HDL-cholesterol and triglycerides were replicated in the DIRECT (pooled P for interaction ≤ 0.01). Similar results on trajectory of changes in HDL cholesterol and triglycerides over the 2 year intervention were observed in both trials. Our study provides replicable evidence that individuals with the CETP rs3764261 CC genotype might derive greater effects on raising HDL cholesterol and lowering triglycerides by choosing a low-carbohydrate/high-fat weight-loss diet instead of a low-fat diet.
KW - Cholesteryl ester transfer protein
KW - Dietary intervention randomized controlled trial
KW - Gene-diet interaction
KW - Preventing overweight using novel dietary strategies
UR - http://www.scopus.com/inward/record.url?scp=84925340970&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925340970&partnerID=8YFLogxK
U2 - 10.1194/jlr.P055715
DO - 10.1194/jlr.P055715
M3 - Article
C2 - 25548261
AN - SCOPUS:84925340970
VL - 56
SP - 713
EP - 721
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 3
ER -