Cervical Papanicolaou smear abnormalities and Chlamydia trachomatis in sexually active adolescent females

M. Edelman, Amy S. Fox, Elizabeth M. Alderman, W. Neal, A. Shapiro, Ellen J. Silver, I. Spigland, Mark J. Suhrland

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Study Objective: To examine the effect of cervical Chlamydia trachomatis infection on the prevalence of Papanicolaou (Pap) smear abnormalities in adolescent females. Design: Retrospective study performed by examination of previously obtained cervical C. trachomatis cultures and Pap smear results. Setting: Urban adolescent health care clinic in the Bronx, New York. Participants: Sexually active females, aged 13 to 23 (mean age: 17.9 years), attending the clinic for evaluation of sexually transmitted diseases. Intervention: Patients who had undergone a gynecological examination with performance of cervical Pap smears and culture for C. trachomatis were enrolled in the study. Main Outcome Measure: Determine the prevalence of cervical C. trachomatis infection and compare cervical smear abnormalities in those with and without infection. Results: Of a study population of 257 females, 24 patients (9.3%) were culture positive for C. trachomatis and 58 patients (22.6%) had significant cervical smear abnormalities, i.e., atypical squamous cells of undetermined significance (ASCUS), low grade squamous intraepithelial lesion (LGSIL), or high grade squamous intraepithelial lesion (HGSIL). The 24 patients infected with C. trachomatis showed the following cervical smear abnormalities: within normal limits - 37.5%, benign cellular changes - 41.7%, ASCUS - 12.5%, and LGSIL - 8.3%. A total of 233 patients (90.7%) were culture negative for C. trachomatis and showed the following cervical smear abnormalities: within normal limits - 37.3%, benign cellular changes - 39.9%, ASCUS - 13.3%, LGSIL - 8.6%, and HGSIL - .9%. Statistical analysis suggested no significant differences between the two groups (P > .9 by the Kruskal-Wallace test). Conclusions: The isolation of C. trachomatis from the cervix of sexually active adolescent females at a single point in time does not impact on the prevalence of significant cervical smear abnormalities.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalJournal of Pediatric and Adolescent Gynecology
Volume13
Issue number2
DOIs
StatePublished - 2000

Fingerprint

Papanicolaou Test
Vaginal Smears
Chlamydia trachomatis
Chlamydia Infections
Urban Health
Gynecological Examination
Sexually Transmitted Diseases
Cervix Uteri
Retrospective Studies
Outcome Assessment (Health Care)
Squamous Intraepithelial Lesions of the Cervix
Delivery of Health Care

Keywords

  • Adolescent
  • Cervix
  • Chlamydia trachomatis
  • HGSIL
  • LGSIL
  • Papanicolaou smear

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

@article{ef7e82fa242b44729d7ff228f73ead6a,
title = "Cervical Papanicolaou smear abnormalities and Chlamydia trachomatis in sexually active adolescent females",
abstract = "Study Objective: To examine the effect of cervical Chlamydia trachomatis infection on the prevalence of Papanicolaou (Pap) smear abnormalities in adolescent females. Design: Retrospective study performed by examination of previously obtained cervical C. trachomatis cultures and Pap smear results. Setting: Urban adolescent health care clinic in the Bronx, New York. Participants: Sexually active females, aged 13 to 23 (mean age: 17.9 years), attending the clinic for evaluation of sexually transmitted diseases. Intervention: Patients who had undergone a gynecological examination with performance of cervical Pap smears and culture for C. trachomatis were enrolled in the study. Main Outcome Measure: Determine the prevalence of cervical C. trachomatis infection and compare cervical smear abnormalities in those with and without infection. Results: Of a study population of 257 females, 24 patients (9.3{\%}) were culture positive for C. trachomatis and 58 patients (22.6{\%}) had significant cervical smear abnormalities, i.e., atypical squamous cells of undetermined significance (ASCUS), low grade squamous intraepithelial lesion (LGSIL), or high grade squamous intraepithelial lesion (HGSIL). The 24 patients infected with C. trachomatis showed the following cervical smear abnormalities: within normal limits - 37.5{\%}, benign cellular changes - 41.7{\%}, ASCUS - 12.5{\%}, and LGSIL - 8.3{\%}. A total of 233 patients (90.7{\%}) were culture negative for C. trachomatis and showed the following cervical smear abnormalities: within normal limits - 37.3{\%}, benign cellular changes - 39.9{\%}, ASCUS - 13.3{\%}, LGSIL - 8.6{\%}, and HGSIL - .9{\%}. Statistical analysis suggested no significant differences between the two groups (P > .9 by the Kruskal-Wallace test). Conclusions: The isolation of C. trachomatis from the cervix of sexually active adolescent females at a single point in time does not impact on the prevalence of significant cervical smear abnormalities.",
keywords = "Adolescent, Cervix, Chlamydia trachomatis, HGSIL, LGSIL, Papanicolaou smear",
author = "M. Edelman and Fox, {Amy S.} and Alderman, {Elizabeth M.} and W. Neal and A. Shapiro and Silver, {Ellen J.} and I. Spigland and Suhrland, {Mark J.}",
year = "2000",
doi = "10.1016/S1083-3188(00)00003-6",
language = "English (US)",
volume = "13",
pages = "65--69",
journal = "Journal of Pediatric and Adolescent Gynecology",
issn = "1083-3188",
publisher = "Elsevier USA",
number = "2",

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TY - JOUR

T1 - Cervical Papanicolaou smear abnormalities and Chlamydia trachomatis in sexually active adolescent females

AU - Edelman, M.

AU - Fox, Amy S.

AU - Alderman, Elizabeth M.

AU - Neal, W.

AU - Shapiro, A.

AU - Silver, Ellen J.

AU - Spigland, I.

AU - Suhrland, Mark J.

PY - 2000

Y1 - 2000

N2 - Study Objective: To examine the effect of cervical Chlamydia trachomatis infection on the prevalence of Papanicolaou (Pap) smear abnormalities in adolescent females. Design: Retrospective study performed by examination of previously obtained cervical C. trachomatis cultures and Pap smear results. Setting: Urban adolescent health care clinic in the Bronx, New York. Participants: Sexually active females, aged 13 to 23 (mean age: 17.9 years), attending the clinic for evaluation of sexually transmitted diseases. Intervention: Patients who had undergone a gynecological examination with performance of cervical Pap smears and culture for C. trachomatis were enrolled in the study. Main Outcome Measure: Determine the prevalence of cervical C. trachomatis infection and compare cervical smear abnormalities in those with and without infection. Results: Of a study population of 257 females, 24 patients (9.3%) were culture positive for C. trachomatis and 58 patients (22.6%) had significant cervical smear abnormalities, i.e., atypical squamous cells of undetermined significance (ASCUS), low grade squamous intraepithelial lesion (LGSIL), or high grade squamous intraepithelial lesion (HGSIL). The 24 patients infected with C. trachomatis showed the following cervical smear abnormalities: within normal limits - 37.5%, benign cellular changes - 41.7%, ASCUS - 12.5%, and LGSIL - 8.3%. A total of 233 patients (90.7%) were culture negative for C. trachomatis and showed the following cervical smear abnormalities: within normal limits - 37.3%, benign cellular changes - 39.9%, ASCUS - 13.3%, LGSIL - 8.6%, and HGSIL - .9%. Statistical analysis suggested no significant differences between the two groups (P > .9 by the Kruskal-Wallace test). Conclusions: The isolation of C. trachomatis from the cervix of sexually active adolescent females at a single point in time does not impact on the prevalence of significant cervical smear abnormalities.

AB - Study Objective: To examine the effect of cervical Chlamydia trachomatis infection on the prevalence of Papanicolaou (Pap) smear abnormalities in adolescent females. Design: Retrospective study performed by examination of previously obtained cervical C. trachomatis cultures and Pap smear results. Setting: Urban adolescent health care clinic in the Bronx, New York. Participants: Sexually active females, aged 13 to 23 (mean age: 17.9 years), attending the clinic for evaluation of sexually transmitted diseases. Intervention: Patients who had undergone a gynecological examination with performance of cervical Pap smears and culture for C. trachomatis were enrolled in the study. Main Outcome Measure: Determine the prevalence of cervical C. trachomatis infection and compare cervical smear abnormalities in those with and without infection. Results: Of a study population of 257 females, 24 patients (9.3%) were culture positive for C. trachomatis and 58 patients (22.6%) had significant cervical smear abnormalities, i.e., atypical squamous cells of undetermined significance (ASCUS), low grade squamous intraepithelial lesion (LGSIL), or high grade squamous intraepithelial lesion (HGSIL). The 24 patients infected with C. trachomatis showed the following cervical smear abnormalities: within normal limits - 37.5%, benign cellular changes - 41.7%, ASCUS - 12.5%, and LGSIL - 8.3%. A total of 233 patients (90.7%) were culture negative for C. trachomatis and showed the following cervical smear abnormalities: within normal limits - 37.3%, benign cellular changes - 39.9%, ASCUS - 13.3%, LGSIL - 8.6%, and HGSIL - .9%. Statistical analysis suggested no significant differences between the two groups (P > .9 by the Kruskal-Wallace test). Conclusions: The isolation of C. trachomatis from the cervix of sexually active adolescent females at a single point in time does not impact on the prevalence of significant cervical smear abnormalities.

KW - Adolescent

KW - Cervix

KW - Chlamydia trachomatis

KW - HGSIL

KW - LGSIL

KW - Papanicolaou smear

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