Cervical infection with cutaneous beta and mucosal alpha papillomaviruses

Ludwig-McGill Cohort Study

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection. Methods: We used Luminex and PCR hybridization to detect band α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both band α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities. Results: Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively, P = 0.034). β-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15%; P = 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with a-9 or a-6 HPV types. We found no epidemiologic correlates for β-HPV infections. Conclusions: Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs. Impact: Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis. Cancer Epidemiol Biomarkers Prev; 26(8); 1312-20.

Original languageEnglish (US)
Pages (from-to)1312-1320
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Volume26
Issue number8
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

Fingerprint

Skin
Infection
Human papillomavirus 6
Papillomavirus Infections
Tumor Biomarkers
Parity
Cervix Uteri
Uterine Cervical Neoplasms
Sexual Behavior
Carcinogenesis
Epidemiology
Cohort Studies
Genotype
Viruses
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Cervical infection with cutaneous beta and mucosal alpha papillomaviruses. / Ludwig-McGill Cohort Study.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 26, No. 8, 01.08.2017, p. 1312-1320.

Research output: Contribution to journalArticle

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title = "Cervical infection with cutaneous beta and mucosal alpha papillomaviruses",
abstract = "Background: Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection. Methods: We used Luminex and PCR hybridization to detect band α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both band α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities. Results: Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3{\%} vs. 21.6{\%}, respectively, P = 0.034). β-HPVs were mostly transient; however, only 1.98{\%} women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15{\%}; P = 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with a-9 or a-6 HPV types. We found no epidemiologic correlates for β-HPV infections. Conclusions: Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs. Impact: Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis. Cancer Epidemiol Biomarkers Prev; 26(8); 1312-20.",
author = "{Ludwig-McGill Cohort Study} and Laura Sichero and Mariam El-Zein and Nunes, {Emily M.} and Silvaneide Ferreira and Franco, {Eduardo L.} and Villa, {Luisa L.} and Baggio, {Maria Luiza} and Lenice Galan and Sobrinho, {Jo{\~a}o Sim{\~a}o} and Prado, {Jos{\'e} Carlos Mann} and Lara Termini and Costa, {Maria Cec{\'i}lia} and Romulo Miyamura and Andrea Trevisan and Patricia Thomann and Jo{\~a}o Candeias and Paula Rahal and Antonio Ruiz and Jane Kaiano and Monica Santos and Patricia Savio and Paulo Maciag and Tatiana Rabachini and Luisa Villa and Rousseau, {Marie Claude} and Salaheddin Mahmud and Nicolas Schlecht and Helen Trottier and Harriet Richardson and Alex Ferenczy and Rohan, {Thomas E.} and Myriam Chevarie-Davis and Karolina Louvanto and Joseph Tota and Eileen Shaw and Agnihotram Ramanakumar and Eliane Duarte and Sophie Kulaga and Juliette Robitaille and Eduardo Franco",
year = "2017",
month = "8",
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doi = "10.1158/1055-9965.EPI-17-0081",
language = "English (US)",
volume = "26",
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journal = "Cancer Epidemiology Biomarkers and Prevention",
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T1 - Cervical infection with cutaneous beta and mucosal alpha papillomaviruses

AU - Ludwig-McGill Cohort Study

AU - Sichero, Laura

AU - El-Zein, Mariam

AU - Nunes, Emily M.

AU - Ferreira, Silvaneide

AU - Franco, Eduardo L.

AU - Villa, Luisa L.

AU - Baggio, Maria Luiza

AU - Galan, Lenice

AU - Sobrinho, João Simão

AU - Prado, José Carlos Mann

AU - Termini, Lara

AU - Costa, Maria Cecília

AU - Miyamura, Romulo

AU - Trevisan, Andrea

AU - Thomann, Patricia

AU - Candeias, João

AU - Rahal, Paula

AU - Ruiz, Antonio

AU - Kaiano, Jane

AU - Santos, Monica

AU - Savio, Patricia

AU - Maciag, Paulo

AU - Rabachini, Tatiana

AU - Villa, Luisa

AU - Rousseau, Marie Claude

AU - Mahmud, Salaheddin

AU - Schlecht, Nicolas

AU - Trottier, Helen

AU - Richardson, Harriet

AU - Ferenczy, Alex

AU - Rohan, Thomas E.

AU - Chevarie-Davis, Myriam

AU - Louvanto, Karolina

AU - Tota, Joseph

AU - Shaw, Eileen

AU - Ramanakumar, Agnihotram

AU - Duarte, Eliane

AU - Kulaga, Sophie

AU - Robitaille, Juliette

AU - Franco, Eduardo

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background: Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection. Methods: We used Luminex and PCR hybridization to detect band α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both band α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities. Results: Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively, P = 0.034). β-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15%; P = 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with a-9 or a-6 HPV types. We found no epidemiologic correlates for β-HPV infections. Conclusions: Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs. Impact: Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis. Cancer Epidemiol Biomarkers Prev; 26(8); 1312-20.

AB - Background: Alpha-human papillomavirus (α-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (β-HPV) infection. Methods: We used Luminex and PCR hybridization to detect band α-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both band α-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities. Results: Infection with β-HPV types was more prevalent than that with α-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively, P = 0.034). β-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for α-HPVs (5.15%; P = 0.007). Age, parity, and sexual activity variables were predictors of α-HPV but not of β-HPV. α- and β-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with a-9 or a-6 HPV types. We found no epidemiologic correlates for β-HPV infections. Conclusions: Detection of β-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by α-HPVs. Impact: Although it is plausible that β-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis. Cancer Epidemiol Biomarkers Prev; 26(8); 1312-20.

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U2 - 10.1158/1055-9965.EPI-17-0081

DO - 10.1158/1055-9965.EPI-17-0081

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AN - SCOPUS:85021936596

VL - 26

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JO - Cancer Epidemiology Biomarkers and Prevention

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