Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon

Adebola Adedimeji; Rogers Ajeh; Anastase Dzudie; Ernestine Kendowo; Norbert Fuhngwa; Denis Nsame; Andre Gaetan Simo-Wambo; Enow Orock; Tiffany M. Hebert; Amanda J. Pierz; Daniel Murokora; Kathryn Anastos; Philip E. Castle

doi:10.1016/j.jcv.2020.104445

Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon

Adebola Adedimeji, Rogers Ajeh, Anastase Dzudie, Ernestine Kendowo, Norbert Fuhngwa, Denis Nsame, Andre Gaetan Simo-Wambo, Enow Orock, Tiffany M. Hebert, Amanda J. Pierz, Daniel Murokora, Kathryn Anastos, Philip E. Castle

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: There are limited data on cervical HPV prevalence in Cameroon and none from its Anglophone region. We investigated cervical HPV prevalence in HIV-uninfected (HIV[-]) and HIV-infected (WLWH) women living in the region. Methods: A convenience sample of consecutively recruited HIV[-] women (n = 295) and women living with HIV (WLWH) (n = 560) attending the Limbé Regional Hospital were enrolled into a cervical screening study. Women underwent screening that included HPV testing of self-collected and provider-collected specimens. We calculated the HPV prevalence by HIV status, overall and stratified by age, and among WLWH, stratified by CD4 counts. We compared the concordance for the detection of HPV between self- and provider-collected specimens. Results: Crude HPV prevalence was 21.69 % (95 % confidence interval [95 %CI] = 17.21–26.48 %) for HIV[-] women and 46.43 % (95 %CI = 42.24–50.66 %) for WLWH (p < 0.001). Among WLWH, older age (p_trend = 0.01) and higher CD4 counts (p_trend = 0.007) were associated with lower HPV prevalence. There was a good-to-excellent agreement for HPV detection between specimens, and self-collected were more likely than provider-collected specimens to test HPV positive, for all women and stratified by HIV status. Conclusions: HIV-related immunosuppression was a risk factor for HPV prevalence in this population. HPV testing of self-collected specimens appeared to be less specific than HPV testing of provider-collected specimens.

Original language	English (US)
Article number	104445
Journal	Journal of Clinical Virology
Volume	128
DOIs	https://doi.org/10.1016/j.jcv.2020.104445
State	Published - Jul 2020

Keywords

Cervical cancer
Human immunodeficiency virus (HIV)
Human papillomavirus (HPV)
Screening
Self-collection

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1016/j.jcv.2020.104445

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Adedimeji, A., Ajeh, R., Dzudie, A., Kendowo, E., Fuhngwa, N., Nsame, D., Simo-Wambo, A. G., Orock, E., Hebert, T. M., Pierz, A. J., Murokora, D., Anastos, K., & Castle, P. E. (2020). Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon. Journal of Clinical Virology, 128, [104445]. https://doi.org/10.1016/j.jcv.2020.104445

Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon. / Adedimeji, Adebola; Ajeh, Rogers; Dzudie, Anastase; Kendowo, Ernestine; Fuhngwa, Norbert; Nsame, Denis; Simo-Wambo, Andre Gaetan; Orock, Enow; Hebert, Tiffany M.; Pierz, Amanda J.; Murokora, Daniel; Anastos, Kathryn; Castle, Philip E.

In: Journal of Clinical Virology, Vol. 128, 104445, 07.2020.

Research output: Contribution to journal › Article › peer-review

Adedimeji, A, Ajeh, R, Dzudie, A, Kendowo, E, Fuhngwa, N, Nsame, D, Simo-Wambo, AG, Orock, E, Hebert, TM, Pierz, AJ, Murokora, D, Anastos, K & Castle, PE 2020, 'Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon', Journal of Clinical Virology, vol. 128, 104445. https://doi.org/10.1016/j.jcv.2020.104445

Adedimeji, Adebola ; Ajeh, Rogers ; Dzudie, Anastase ; Kendowo, Ernestine ; Fuhngwa, Norbert ; Nsame, Denis ; Simo-Wambo, Andre Gaetan ; Orock, Enow ; Hebert, Tiffany M. ; Pierz, Amanda J. ; Murokora, Daniel ; Anastos, Kathryn ; Castle, Philip E. / Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon. In: Journal of Clinical Virology. 2020 ; Vol. 128.

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title = "Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon",

abstract = "Background: There are limited data on cervical HPV prevalence in Cameroon and none from its Anglophone region. We investigated cervical HPV prevalence in HIV-uninfected (HIV[-]) and HIV-infected (WLWH) women living in the region. Methods: A convenience sample of consecutively recruited HIV[-] women (n = 295) and women living with HIV (WLWH) (n = 560) attending the Limb{\'e} Regional Hospital were enrolled into a cervical screening study. Women underwent screening that included HPV testing of self-collected and provider-collected specimens. We calculated the HPV prevalence by HIV status, overall and stratified by age, and among WLWH, stratified by CD4 counts. We compared the concordance for the detection of HPV between self- and provider-collected specimens. Results: Crude HPV prevalence was 21.69 % (95 % confidence interval [95 %CI] = 17.21–26.48 %) for HIV[-] women and 46.43 % (95 %CI = 42.24–50.66 %) for WLWH (p < 0.001). Among WLWH, older age (ptrend = 0.01) and higher CD4 counts (ptrend = 0.007) were associated with lower HPV prevalence. There was a good-to-excellent agreement for HPV detection between specimens, and self-collected were more likely than provider-collected specimens to test HPV positive, for all women and stratified by HIV status. Conclusions: HIV-related immunosuppression was a risk factor for HPV prevalence in this population. HPV testing of self-collected specimens appeared to be less specific than HPV testing of provider-collected specimens.",

keywords = "Cervical cancer, Human immunodeficiency virus (HIV), Human papillomavirus (HPV), Screening, Self-collection",

author = "Adebola Adedimeji and Rogers Ajeh and Anastase Dzudie and Ernestine Kendowo and Norbert Fuhngwa and Denis Nsame and Simo-Wambo, {Andre Gaetan} and Enow Orock and Hebert, {Tiffany M.} and Pierz, {Amanda J.} and Daniel Murokora and Kathryn Anastos and Castle, {Philip E.}",

note = "Funding Information: Research reported in this publication was supported by a supplement (3P30CA013330) from the National Cancer Institute to the Albert Einstein College of Medicine Cancer Center. Additional funding from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number U01AI096299 (PI: Anastos, Nash and Yotebieng) to the Albert Einstein College of Medicine supported this study. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: Research reported in this publication was supported by a supplement ( 3P30CA013330 ) from the National Cancer Institute to the Albert Einstein College of Medicine Cancer Center . Additional funding from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number U01AI096299 (PI: Anastos, Nash and Yotebieng) to the Albert Einstein College of Medicine supported this study. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = jul,

doi = "10.1016/j.jcv.2020.104445",

language = "English (US)",

volume = "128",

journal = "Journal of Clinical Virology",

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TY - JOUR

T1 - Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon

AU - Adedimeji, Adebola

AU - Ajeh, Rogers

AU - Dzudie, Anastase

AU - Kendowo, Ernestine

AU - Fuhngwa, Norbert

AU - Nsame, Denis

AU - Simo-Wambo, Andre Gaetan

AU - Orock, Enow

AU - Hebert, Tiffany M.

AU - Pierz, Amanda J.

AU - Murokora, Daniel

AU - Anastos, Kathryn

AU - Castle, Philip E.

N1 - Funding Information: Research reported in this publication was supported by a supplement (3P30CA013330) from the National Cancer Institute to the Albert Einstein College of Medicine Cancer Center. Additional funding from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number U01AI096299 (PI: Anastos, Nash and Yotebieng) to the Albert Einstein College of Medicine supported this study. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: Research reported in this publication was supported by a supplement ( 3P30CA013330 ) from the National Cancer Institute to the Albert Einstein College of Medicine Cancer Center . Additional funding from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number U01AI096299 (PI: Anastos, Nash and Yotebieng) to the Albert Einstein College of Medicine supported this study. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2020 Elsevier B.V.

PY - 2020/7

Y1 - 2020/7

N2 - Background: There are limited data on cervical HPV prevalence in Cameroon and none from its Anglophone region. We investigated cervical HPV prevalence in HIV-uninfected (HIV[-]) and HIV-infected (WLWH) women living in the region. Methods: A convenience sample of consecutively recruited HIV[-] women (n = 295) and women living with HIV (WLWH) (n = 560) attending the Limbé Regional Hospital were enrolled into a cervical screening study. Women underwent screening that included HPV testing of self-collected and provider-collected specimens. We calculated the HPV prevalence by HIV status, overall and stratified by age, and among WLWH, stratified by CD4 counts. We compared the concordance for the detection of HPV between self- and provider-collected specimens. Results: Crude HPV prevalence was 21.69 % (95 % confidence interval [95 %CI] = 17.21–26.48 %) for HIV[-] women and 46.43 % (95 %CI = 42.24–50.66 %) for WLWH (p < 0.001). Among WLWH, older age (ptrend = 0.01) and higher CD4 counts (ptrend = 0.007) were associated with lower HPV prevalence. There was a good-to-excellent agreement for HPV detection between specimens, and self-collected were more likely than provider-collected specimens to test HPV positive, for all women and stratified by HIV status. Conclusions: HIV-related immunosuppression was a risk factor for HPV prevalence in this population. HPV testing of self-collected specimens appeared to be less specific than HPV testing of provider-collected specimens.

AB - Background: There are limited data on cervical HPV prevalence in Cameroon and none from its Anglophone region. We investigated cervical HPV prevalence in HIV-uninfected (HIV[-]) and HIV-infected (WLWH) women living in the region. Methods: A convenience sample of consecutively recruited HIV[-] women (n = 295) and women living with HIV (WLWH) (n = 560) attending the Limbé Regional Hospital were enrolled into a cervical screening study. Women underwent screening that included HPV testing of self-collected and provider-collected specimens. We calculated the HPV prevalence by HIV status, overall and stratified by age, and among WLWH, stratified by CD4 counts. We compared the concordance for the detection of HPV between self- and provider-collected specimens. Results: Crude HPV prevalence was 21.69 % (95 % confidence interval [95 %CI] = 17.21–26.48 %) for HIV[-] women and 46.43 % (95 %CI = 42.24–50.66 %) for WLWH (p < 0.001). Among WLWH, older age (ptrend = 0.01) and higher CD4 counts (ptrend = 0.007) were associated with lower HPV prevalence. There was a good-to-excellent agreement for HPV detection between specimens, and self-collected were more likely than provider-collected specimens to test HPV positive, for all women and stratified by HIV status. Conclusions: HIV-related immunosuppression was a risk factor for HPV prevalence in this population. HPV testing of self-collected specimens appeared to be less specific than HPV testing of provider-collected specimens.

KW - Cervical cancer

KW - Human immunodeficiency virus (HIV)

KW - Human papillomavirus (HPV)

KW - Screening

KW - Self-collection

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DO - 10.1016/j.jcv.2020.104445

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JO - Journal of Clinical Virology

JF - Journal of Clinical Virology

SN - 1386-6532

M1 - 104445

ER -

Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon

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Keywords

ASJC Scopus subject areas

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