Cervical cytologic abnormalities and papillomavirus in women infected with human immunodeficiency virus

Anat R. Feingold, Sten H. Vermund, Robert D. Burk, Karen F. Kelley, Lewis K. Schrager, Klaus Schreiber, Gary Munk, Gerald H. Friedland, Robert S. Klein

Research output: Contribution to journalArticle

151 Scopus citations

Abstract

We investigated the relationship of human papillomavirus (HPV) infection of the female genital tract, cervical cytology, and human immunodeficiency virus (HIV) infection in 67 women. Forty-eight women had a history of intravenous drug use, 18 were heterosexual partners of HIV-infected intravenous drug users, and one was a transfusion recipient. Patients received a Pap smear, cervicovaginal lavage for HPV determination by Southern blot, HIV serum antibody by enzyme immunoassay with Western blot confirmation, and thorough screening for other sexually transmitted diseases. Seventeen of the 35 (49%) women seropositive for HIV had HPV infection, compared with 8 of 32 (25%) seronegative women (p <0.05). Fourteen of 35 (40%) HIV-positive women had squamous intraepithelial lesions (SIL) on cervical cytology, compared with three of 32 (9%) HIV-negative women (p <0.01). Of 22 women with symptomatic HIV infection, 11 (50%) had SIL on cytology; 10 of these 11 were HPV-positive. Among 13 asymptomatic HIV-positive women, only three (23%) had such cytological lesions. Our findings strongly suggest that HIV-induced immunosuppression exacerbates HPV-mediated cervical cytologic abnormalities.

Original languageEnglish (US)
Pages (from-to)896-903
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume3
Issue number9
StatePublished - Sep 1990

Keywords

  • Human immunodeficiency virus
  • Human papillomavirus
  • Squamous intraepithelial lesion

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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    Feingold, A. R., Vermund, S. H., Burk, R. D., Kelley, K. F., Schrager, L. K., Schreiber, K., Munk, G., Friedland, G. H., & Klein, R. S. (1990). Cervical cytologic abnormalities and papillomavirus in women infected with human immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes, 3(9), 896-903.