Cerebral lesions in congenital rubella syndrome

Lucy Balian Rorke, Alfred J. Spiro

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Abstract

Study of the brains of 9 infants less than 1 year of age with congenital rubella syndrome revealed extensive degenerative changes in leptomeningeal and intrinsic arteries and veins of the cerebrum. Vascular damage was associated with foci of necrosis localized chiefly in the deep white matter and gray nuclei. There was retardation in myelinization of selected neural systems in 5 of 8 infants surviving for more than one month. No developmental malformations or significant inflammation of the nervous system was found in the group.

Original languageEnglish (US)
Pages (from-to)243-247,249-255
JournalThe Journal of Pediatrics
Volume70
Issue number2
DOIs
Publication statusPublished - Feb 1967

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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