Study of the brains of 9 infants less than 1 year of age with congenital rubella syndrome revealed extensive degenerative changes in leptomeningeal and intrinsic arteries and veins of the cerebrum. Vascular damage was associated with foci of necrosis localized chiefly in the deep white matter and gray nuclei. There was retardation in myelinization of selected neural systems in 5 of 8 infants surviving for more than one month. No developmental malformations or significant inflammation of the nervous system was found in the group.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health