Cerebral blood flow measured by NMR indicator dilution in cats

James R. Ewing, Craig A. Branch, Joseph A. Helpern, Michael B. Smith, Shazad M. Butt, K. M A Welch

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We developed techniques to assess the utility of a nuclear magnetic resonance (NMR) indicator for cerebral blood flow studies in cats, using Freon-22 for the first candidate. A PIN-diode-switched NMR experiment allowed the acquisition of an arterial as well as a cerebral fluorine-19 signal proportional to concentration vs. tune in a 1.89 T magnet. Mean±SD blood:brain partition coefficients for Freon-22 were estimated at 0.93±0.08 for gray matter and 0.77±0.12 for white matter. Using maximum-likelihood curve fitting, estimates of mean±SD resting cerebral blood flow were 50±19 ml/100 g-min for gray matter and 5.0±2.0 ml/100 g-min for white matter. Hypercapnia produced the expected increases in gray and white matter blood flow. The physiologic effects of Freon-22, including an increase in cerebral blood flow itself with administration of 40% by volume, may limit its use as an indicator. Nevertheless, the NMR techniques described demonstrate the feasibility of fluorine-19-labeled compounds as cerebral blood flow indicators and the promise for their use in humans.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalStroke
Volume20
Issue number2
StatePublished - 1989
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Cats
Magnetic Resonance Spectroscopy
Fluorine
Magnets
Hypercapnia
Brain
fluorocarbon 22
Gray Matter
White Matter

Keywords

  • Cats
  • Cerebral blood flow
  • Nuclear magnetic resonance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Ewing, J. R., Branch, C. A., Helpern, J. A., Smith, M. B., Butt, S. M., & Welch, K. M. A. (1989). Cerebral blood flow measured by NMR indicator dilution in cats. Stroke, 20(2), 259-267.

Cerebral blood flow measured by NMR indicator dilution in cats. / Ewing, James R.; Branch, Craig A.; Helpern, Joseph A.; Smith, Michael B.; Butt, Shazad M.; Welch, K. M A.

In: Stroke, Vol. 20, No. 2, 1989, p. 259-267.

Research output: Contribution to journalArticle

Ewing, JR, Branch, CA, Helpern, JA, Smith, MB, Butt, SM & Welch, KMA 1989, 'Cerebral blood flow measured by NMR indicator dilution in cats', Stroke, vol. 20, no. 2, pp. 259-267.
Ewing JR, Branch CA, Helpern JA, Smith MB, Butt SM, Welch KMA. Cerebral blood flow measured by NMR indicator dilution in cats. Stroke. 1989;20(2):259-267.
Ewing, James R. ; Branch, Craig A. ; Helpern, Joseph A. ; Smith, Michael B. ; Butt, Shazad M. ; Welch, K. M A. / Cerebral blood flow measured by NMR indicator dilution in cats. In: Stroke. 1989 ; Vol. 20, No. 2. pp. 259-267.
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