Abstract
We developed techniques to assess the utility of a nuclear magnetic resonance (NMR) indicator for cerebral blood flow studies in cats, using Freon-22 for the first candidate. A PIN-diode-switched NMR experiment allowed the acquisition of an arterial as well as a cerebral fluorine-19 signal proportional to concentration vs. tune in a 1.89 T magnet. Mean±SD blood:brain partition coefficients for Freon-22 were estimated at 0.93±0.08 for gray matter and 0.77±0.12 for white matter. Using maximum-likelihood curve fitting, estimates of mean±SD resting cerebral blood flow were 50±19 ml/100 g-min for gray matter and 5.0±2.0 ml/100 g-min for white matter. Hypercapnia produced the expected increases in gray and white matter blood flow. The physiologic effects of Freon-22, including an increase in cerebral blood flow itself with administration of 40% by volume, may limit its use as an indicator. Nevertheless, the NMR techniques described demonstrate the feasibility of fluorine-19-labeled compounds as cerebral blood flow indicators and the promise for their use in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 259-267 |
| Number of pages | 9 |
| Journal | Stroke |
| Volume | 20 |
| Issue number | 2 |
| State | Published - 1989 |
| Externally published | Yes |
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Keywords
- Cats
- Cerebral blood flow
- Nuclear magnetic resonance
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Advanced and Specialized Nursing
- Neuroscience(all)
Cite this
Cerebral blood flow measured by NMR indicator dilution in cats. / Ewing, James R.; Branch, Craig A.; Helpern, Joseph A.; Smith, Michael B.; Butt, Shazad M.; Welch, K. M A.
In: Stroke, Vol. 20, No. 2, 1989, p. 259-267.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral blood flow measured by NMR indicator dilution in cats
AU - Ewing, James R.
AU - Branch, Craig A.
AU - Helpern, Joseph A.
AU - Smith, Michael B.
AU - Butt, Shazad M.
AU - Welch, K. M A
PY - 1989
Y1 - 1989
N2 - We developed techniques to assess the utility of a nuclear magnetic resonance (NMR) indicator for cerebral blood flow studies in cats, using Freon-22 for the first candidate. A PIN-diode-switched NMR experiment allowed the acquisition of an arterial as well as a cerebral fluorine-19 signal proportional to concentration vs. tune in a 1.89 T magnet. Mean±SD blood:brain partition coefficients for Freon-22 were estimated at 0.93±0.08 for gray matter and 0.77±0.12 for white matter. Using maximum-likelihood curve fitting, estimates of mean±SD resting cerebral blood flow were 50±19 ml/100 g-min for gray matter and 5.0±2.0 ml/100 g-min for white matter. Hypercapnia produced the expected increases in gray and white matter blood flow. The physiologic effects of Freon-22, including an increase in cerebral blood flow itself with administration of 40% by volume, may limit its use as an indicator. Nevertheless, the NMR techniques described demonstrate the feasibility of fluorine-19-labeled compounds as cerebral blood flow indicators and the promise for their use in humans.
AB - We developed techniques to assess the utility of a nuclear magnetic resonance (NMR) indicator for cerebral blood flow studies in cats, using Freon-22 for the first candidate. A PIN-diode-switched NMR experiment allowed the acquisition of an arterial as well as a cerebral fluorine-19 signal proportional to concentration vs. tune in a 1.89 T magnet. Mean±SD blood:brain partition coefficients for Freon-22 were estimated at 0.93±0.08 for gray matter and 0.77±0.12 for white matter. Using maximum-likelihood curve fitting, estimates of mean±SD resting cerebral blood flow were 50±19 ml/100 g-min for gray matter and 5.0±2.0 ml/100 g-min for white matter. Hypercapnia produced the expected increases in gray and white matter blood flow. The physiologic effects of Freon-22, including an increase in cerebral blood flow itself with administration of 40% by volume, may limit its use as an indicator. Nevertheless, the NMR techniques described demonstrate the feasibility of fluorine-19-labeled compounds as cerebral blood flow indicators and the promise for their use in humans.
KW - Cats
KW - Cerebral blood flow
KW - Nuclear magnetic resonance
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UR - http://www.scopus.com/inward/citedby.url?scp=0024593807&partnerID=8YFLogxK
M3 - Article
C2 - 2645693
AN - SCOPUS:0024593807
VL - 20
SP - 259
EP - 267
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 2
ER -