Cerebellar modulation of the reward circuitry and social behavior

Ilaria Carta, Christopher H. Chen, Amanda L. Schott, Schnaude Dorizan, Kamran Khodakhah

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The cerebellum has been implicated in a number of nonmotor mental disorders such as autism spectrum disorder, schizophrenia, and addiction. However, its contribution to these disorders is not well understood. In mice, we found that the cerebellum sends direct excitatory projections to the ventral tegmental area (VTA), one of the brain regions that processes and encodes reward. Optogenetic activation of the cerebello-VTA projections was rewarding and, in a three-chamber social task, these projections were more active when the animal explored the social chamber. Intriguingly, activity in the cerebello-VTA pathway was required for the mice to show social preference in this task. Our data delineate a major, previously unappreciated role for the cerebellum in controlling the reward circuitry and social behavior.

Original languageEnglish (US)
Article numbereaav0581
JournalScience
Volume363
Issue number6424
DOIs
StatePublished - Jan 18 2019

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Ventral Tegmental Area
Social Behavior
Reward
Cerebellum
Optogenetics
Mental Disorders
Schizophrenia
Brain

ASJC Scopus subject areas

  • General

Cite this

Carta, I., Chen, C. H., Schott, A. L., Dorizan, S., & Khodakhah, K. (2019). Cerebellar modulation of the reward circuitry and social behavior. Science, 363(6424), [eaav0581]. https://doi.org/10.1126/science.aav0581

Cerebellar modulation of the reward circuitry and social behavior. / Carta, Ilaria; Chen, Christopher H.; Schott, Amanda L.; Dorizan, Schnaude; Khodakhah, Kamran.

In: Science, Vol. 363, No. 6424, eaav0581, 18.01.2019.

Research output: Contribution to journalArticle

Carta, I, Chen, CH, Schott, AL, Dorizan, S & Khodakhah, K 2019, 'Cerebellar modulation of the reward circuitry and social behavior', Science, vol. 363, no. 6424, eaav0581. https://doi.org/10.1126/science.aav0581
Carta, Ilaria ; Chen, Christopher H. ; Schott, Amanda L. ; Dorizan, Schnaude ; Khodakhah, Kamran. / Cerebellar modulation of the reward circuitry and social behavior. In: Science. 2019 ; Vol. 363, No. 6424.
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