Cerebellar degeneration in neuroleptic malignant syndrome: Neuropathologic findings and review of the literature concerning heat-related nervous system injury

S. Lee, A. Merriam, T. S. Kim, M. Liebling, D. W. Dickson, G. R W Moore

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

A selective subtotal cerebellar neuronal degeneration was found in a patient who died 4 1/2 months after suffering neuroleptic malignant syndrome (NMS), a rare, potentially fatal disorder associated with neuroleptic medications. It is suggested that the cerebellar neuronal degeneration in this case was due to hyperpyrexia, a cardial clinical feature of NMS. Similar pathologic findings appear not to have been previously reported in NMS but have been described in heat-induced central nervous system (CNS) injury. The findings imply that a cerebellar syndrome might be encountered in patients who survive NMS complicated by a particularly high febrile course.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume52
Issue number3
StatePublished - 1989

Fingerprint

Neuroleptic Malignant Syndrome
Nervous System Trauma
Hot Temperature
Cerebellar Diseases
Antipsychotic Agents
Fever
Central Nervous System

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Cerebellar degeneration in neuroleptic malignant syndrome : Neuropathologic findings and review of the literature concerning heat-related nervous system injury. / Lee, S.; Merriam, A.; Kim, T. S.; Liebling, M.; Dickson, D. W.; Moore, G. R W.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 52, No. 3, 1989, p. 387-391.

Research output: Contribution to journalArticle

@article{094dd417a0b742e89f44f53d0f6dfbce,
title = "Cerebellar degeneration in neuroleptic malignant syndrome: Neuropathologic findings and review of the literature concerning heat-related nervous system injury",
abstract = "A selective subtotal cerebellar neuronal degeneration was found in a patient who died 4 1/2 months after suffering neuroleptic malignant syndrome (NMS), a rare, potentially fatal disorder associated with neuroleptic medications. It is suggested that the cerebellar neuronal degeneration in this case was due to hyperpyrexia, a cardial clinical feature of NMS. Similar pathologic findings appear not to have been previously reported in NMS but have been described in heat-induced central nervous system (CNS) injury. The findings imply that a cerebellar syndrome might be encountered in patients who survive NMS complicated by a particularly high febrile course.",
author = "S. Lee and A. Merriam and Kim, {T. S.} and M. Liebling and Dickson, {D. W.} and Moore, {G. R W}",
year = "1989",
language = "English (US)",
volume = "52",
pages = "387--391",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "3",

}

TY - JOUR

T1 - Cerebellar degeneration in neuroleptic malignant syndrome

T2 - Neuropathologic findings and review of the literature concerning heat-related nervous system injury

AU - Lee, S.

AU - Merriam, A.

AU - Kim, T. S.

AU - Liebling, M.

AU - Dickson, D. W.

AU - Moore, G. R W

PY - 1989

Y1 - 1989

N2 - A selective subtotal cerebellar neuronal degeneration was found in a patient who died 4 1/2 months after suffering neuroleptic malignant syndrome (NMS), a rare, potentially fatal disorder associated with neuroleptic medications. It is suggested that the cerebellar neuronal degeneration in this case was due to hyperpyrexia, a cardial clinical feature of NMS. Similar pathologic findings appear not to have been previously reported in NMS but have been described in heat-induced central nervous system (CNS) injury. The findings imply that a cerebellar syndrome might be encountered in patients who survive NMS complicated by a particularly high febrile course.

AB - A selective subtotal cerebellar neuronal degeneration was found in a patient who died 4 1/2 months after suffering neuroleptic malignant syndrome (NMS), a rare, potentially fatal disorder associated with neuroleptic medications. It is suggested that the cerebellar neuronal degeneration in this case was due to hyperpyrexia, a cardial clinical feature of NMS. Similar pathologic findings appear not to have been previously reported in NMS but have been described in heat-induced central nervous system (CNS) injury. The findings imply that a cerebellar syndrome might be encountered in patients who survive NMS complicated by a particularly high febrile course.

UR - http://www.scopus.com/inward/record.url?scp=0024562353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024562353&partnerID=8YFLogxK

M3 - Article

C2 - 2647908

AN - SCOPUS:0024562353

VL - 52

SP - 387

EP - 391

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 3

ER -