Cerebellar degeneration in neuroleptic malignant syndrome: Neuropathologic findings and review of the literature concerning heat-related nervous system injury

S. Lee, A. Merriam, T. S. Kim, M. Liebling, D. W. Dickson, G. R.W. Moore

Research output: Contribution to journalReview article

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A selective subtotal cerebellar neuronal degeneration was found in a patient who died 4 1/2 months after suffering neuroleptic malignant syndrome (NMS), a rare, potentially fatal disorder associated with neuroleptic medications. It is suggested that the cerebellar neuronal degeneration in this case was due to hyperpyrexia, a cardial clinical feature of NMS. Similar pathologic findings appear not to have been previously reported in NMS but have been described in heat-induced central nervous system (CNS) injury. The findings imply that a cerebellar syndrome might be encountered in patients who survive NMS complicated by a particularly high febrile course.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number3
Publication statusPublished - Jan 1 1989


ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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