TY - JOUR
T1 - Central nervous system manifestations of Angiostrongylus cantonensis infection
AU - Martins, Yuri C.
AU - Tanowitz, Herbert B.
AU - Kazacos, Kevin R.
N1 - Funding Information:
YCM is supported by the Inter-hemispheric Research Fogarty International Center/NIH Global Infectious Disease Research Training Program (D43 TW007129). The funders had no role in data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Over 20 species of Angiostrongylus have been described from around the world, but only Angiostrongylus cantonensis has been confirmed to cause central nervous system disease in humans. A neurotropic parasite that matures in the pulmonary arteries of rats, A. cantonensis is the most common cause of eosinophilic meningitis in southern Asia and the Pacific and Caribbean islands. The parasite can also cause encephalitis/encephalomyelitis and rarely ocular angiostrongyliasis. The present paper reviews the life cycle, epidemiology, pathogenesis, clinical features, diagnosis, treatment, prevention and prognosis of A. cantonesis infection. Emphasis is given on the spectrum of central nervous system manifestations and disease pathogenesis.
AB - Over 20 species of Angiostrongylus have been described from around the world, but only Angiostrongylus cantonensis has been confirmed to cause central nervous system disease in humans. A neurotropic parasite that matures in the pulmonary arteries of rats, A. cantonensis is the most common cause of eosinophilic meningitis in southern Asia and the Pacific and Caribbean islands. The parasite can also cause encephalitis/encephalomyelitis and rarely ocular angiostrongyliasis. The present paper reviews the life cycle, epidemiology, pathogenesis, clinical features, diagnosis, treatment, prevention and prognosis of A. cantonesis infection. Emphasis is given on the spectrum of central nervous system manifestations and disease pathogenesis.
KW - Angiostrongylus cantonensis
KW - Eosinophilic meningitis
KW - Parasitic encephalitis
UR - http://www.scopus.com/inward/record.url?scp=84908374538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908374538&partnerID=8YFLogxK
U2 - 10.1016/j.actatropica.2014.10.002
DO - 10.1016/j.actatropica.2014.10.002
M3 - Review article
C2 - 25312338
AN - SCOPUS:84908374538
SN - 0001-706X
VL - 141
SP - 46
EP - 53
JO - Acta Tropica
JF - Acta Tropica
IS - Part A
ER -
