Central nervous system involvement in AIDS-related lymphomas

Stefan K. Barta, Jitesh Joshi, Nicolas Mounier, Xiaonan Xue, Dan Wang, Josep Maria Ribera, Jose Tomas Navarro, Christian Hoffmann, Kieron Dunleavy, Richard F. Little, Wyndham H. Wilson, Michele Spina, Lionel Galicier, Ariela Noy, Joseph A. Sparano

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Central nervous system (CNS) involvement is reportedly more common in acquired immunodeficiency syndrome (AIDS)-related lymphomas (ARL). We describe factors and outcomes associated with CNS involvement at baseline (CNSB) and relapse (CNSR) in 886 patients with newly diagnosed ARL. Of 886 patients, 800 received either intrathecal (IT) therapy for CNSB or IT prophylaxis. CNSB was found in 13%. CNSB was not associated with reduced overall survival (OS). There was no difference in the prevalence of CNSB between the pre-combination antiretroviral therapy (cART) and cART eras. 5·3% of patients experienced CNSR at a median of 4·2 months after diagnosis (12% if CNSB; 4% if not). Median OS after CNSR was 1·6 months. On multivariate analysis, only CNSB [hazard ratio (HR) 3·68, P = 0·005] and complete response to initial therapy (HR 0·14, P < 0·0001) were significantly associated with CNSR. When restricted to patients without CNSB, IT CNS prophylaxis with 3 vs. 1 agent did not significantly impact the risk of CNSR. Despite IT CNS prophylaxis, 5% of patients experienced CNSR. Our data confirms that CNSR in ARL occurs early and has a poor outcome. Complete response to initial therapy was associated with a reduced frequency of CNSR. Although CNSB conferred an increased risk for CNSR, it did not impact OS.

Original languageEnglish (US)
Pages (from-to)857-866
Number of pages10
JournalBritish Journal of Haematology
Volume173
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • AIDS-related lymphoma
  • acquired immunodeficiency syndrome
  • central nervous system relapse
  • lymphoma
  • non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Barta, S. K., Joshi, J., Mounier, N., Xue, X., Wang, D., Ribera, J. M., Navarro, J. T., Hoffmann, C., Dunleavy, K., Little, R. F., Wilson, W. H., Spina, M., Galicier, L., Noy, A., & Sparano, J. A. (2016). Central nervous system involvement in AIDS-related lymphomas. British Journal of Haematology, 173(6), 857-866. https://doi.org/10.1111/bjh.13998