Central Leucine Sensing in the Control of Energy Homeostasis

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

This article reviews recent studies identifying two key brain regions as two critical nodes in the neural network where central leucine sensing contributes to whole body energy homeostasis: the mediobasal hypothalamus and the dorsal vagal complex of the caudal brainstem. Activation of these leucine sensing sites engages multiple determinants of energy balance, including glucose homeostasis, food intake, and adiposity.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalEndocrinology and Metabolism Clinics of North America
Volume42
Issue number1
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

Keywords

  • Brainstem
  • Diabetes
  • Food intake
  • Hypothalamus
  • Leucine
  • Nutrient sensing
  • Obesity
  • Rapamycin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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