Central Leucine Sensing in the Control of Energy Homeostasis

Gary J. Schwartz

doi:10.1016/j.ecl.2012.12.001

Central Leucine Sensing in the Control of Energy Homeostasis

Gary J. Schwartz

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

This article reviews recent studies identifying two key brain regions as two critical nodes in the neural network where central leucine sensing contributes to whole body energy homeostasis: the mediobasal hypothalamus and the dorsal vagal complex of the caudal brainstem. Activation of these leucine sensing sites engages multiple determinants of energy balance, including glucose homeostasis, food intake, and adiposity.

Original language	English (US)
Pages (from-to)	81-87
Number of pages	7
Journal	Endocrinology and Metabolism Clinics of North America
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.ecl.2012.12.001
State	Published - Mar 2013
Externally published	Yes

Keywords

Brainstem
Diabetes
Food intake
Hypothalamus
Leucine
Nutrient sensing
Obesity
Rapamycin

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ecl.2012.12.001

Cite this

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abstract = "This article reviews recent studies identifying two key brain regions as two critical nodes in the neural network where central leucine sensing contributes to whole body energy homeostasis: the mediobasal hypothalamus and the dorsal vagal complex of the caudal brainstem. Activation of these leucine sensing sites engages multiple determinants of energy balance, including glucose homeostasis, food intake, and adiposity.",

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AB - This article reviews recent studies identifying two key brain regions as two critical nodes in the neural network where central leucine sensing contributes to whole body energy homeostasis: the mediobasal hypothalamus and the dorsal vagal complex of the caudal brainstem. Activation of these leucine sensing sites engages multiple determinants of energy balance, including glucose homeostasis, food intake, and adiposity.

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KW - Diabetes

KW - Food intake

KW - Hypothalamus

KW - Leucine

KW - Nutrient sensing

KW - Obesity

KW - Rapamycin

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Central Leucine Sensing in the Control of Energy Homeostasis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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