Central leptin modulates behavioral and neural responsivity to CCK

Michael Emond, Gary J. Schwartz, Ellen E. Ladenheim, Timothy H. Moran

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

The mechanisms through which leptin, the protein product of the ob gene, affects food intake remain to be determined. To assess whether the actions of leptin depend on modulation of within-meal satiety signals, we measured the effect of third ventricular leptin administration on the satiety actions of CCK. Leptin (10 μg) administered 1 h before 30-min access to a liquid diet had no effect on intake when administered alone, but doses of 3.5 or 10 μg dose dependently increased the suppression of intake produced by 1 nmol/kg CCK. Examination of patterns of c-Fos activation induced by 3.5 μg leptin and 1 nmol/kg CCK revealed that the combination produced significant c-Fos activation within the area postrema and the caudal and medial nucleus of the solitary tract (NST) compared with either leptin or CCK treatments alone. The leptin-CCK combination also resulted in increased c-Fos activation within the paraventricular nucleus of the hypothalamus above that produced by leptin alone. These data suggest that the actions of leptin in food intake are mediated through its ability to modulate responsivity to within-meal satiety signals.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume276
Issue number5 45-5
StatePublished - May 1999
Externally publishedYes

Fingerprint

Leptin
Meals
Eating
Area Postrema
Solitary Nucleus
Paraventricular Hypothalamic Nucleus
Hypothalamus
Diet

Keywords

  • Brain-gut peptide
  • Cholecystokinin
  • Food intake
  • Ingestion
  • ob gene product
  • Satiety

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Central leptin modulates behavioral and neural responsivity to CCK. / Emond, Michael; Schwartz, Gary J.; Ladenheim, Ellen E.; Moran, Timothy H.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 276, No. 5 45-5, 05.1999.

Research output: Contribution to journalArticle

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