Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Yu Fang, Xiaoxin Chen, Manisha Bajpai, Amit Verma, Kiron M. Das, Rhonda F. Souza, Katherine S. Garman, Claire L. Donohoe, Naoimh J. O'Farrell, John V. Reynolds, Katerina Dvorak

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

Original languageEnglish (US)
Pages (from-to)187-199
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume1300
Issue number1
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • Autophagy
  • Barrett's esophagus
  • DNA methylation
  • Esophageal adenocarcinoma
  • Obesity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Fang, Y., Chen, X., Bajpai, M., Verma, A., Das, K. M., Souza, R. F., Garman, K. S., Donohoe, C. L., O'Farrell, N. J., Reynolds, J. V., & Dvorak, K. (2013). Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma. Annals of the New York Academy of Sciences, 1300(1), 187-199. https://doi.org/10.1111/nyas.12249