Cellular genomic maps help dissect pathology in human skin disease

Asifa S. Haider, Michelle A. Lowes, Mayte Suàrez-Fariñas, Lisa C. Zaba, Irma Cardinale, Miroslav Blumenberg, James G. Krueger

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined "lineage-specific" genes, as well as " activation" genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps.

Original languageEnglish (US)
Pages (from-to)606-615
Number of pages10
JournalJournal of Investigative Dermatology
Volume128
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

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Pathology
Skin Diseases
Skin
Genes
Dendritic Cells
Gene Components
Keratinocytes
Psoriasis
T-cells
Macrophages
Monocytes
Fibroblasts
T-Lymphocytes
Chemical activation

ASJC Scopus subject areas

  • Dermatology

Cite this

Haider, A. S., Lowes, M. A., Suàrez-Fariñas, M., Zaba, L. C., Cardinale, I., Blumenberg, M., & Krueger, J. G. (2008). Cellular genomic maps help dissect pathology in human skin disease. Journal of Investigative Dermatology, 128(3), 606-615. https://doi.org/10.1038/sj.jid.5701067

Cellular genomic maps help dissect pathology in human skin disease. / Haider, Asifa S.; Lowes, Michelle A.; Suàrez-Fariñas, Mayte; Zaba, Lisa C.; Cardinale, Irma; Blumenberg, Miroslav; Krueger, James G.

In: Journal of Investigative Dermatology, Vol. 128, No. 3, 03.2008, p. 606-615.

Research output: Contribution to journalArticle

Haider, AS, Lowes, MA, Suàrez-Fariñas, M, Zaba, LC, Cardinale, I, Blumenberg, M & Krueger, JG 2008, 'Cellular genomic maps help dissect pathology in human skin disease', Journal of Investigative Dermatology, vol. 128, no. 3, pp. 606-615. https://doi.org/10.1038/sj.jid.5701067
Haider AS, Lowes MA, Suàrez-Fariñas M, Zaba LC, Cardinale I, Blumenberg M et al. Cellular genomic maps help dissect pathology in human skin disease. Journal of Investigative Dermatology. 2008 Mar;128(3):606-615. https://doi.org/10.1038/sj.jid.5701067
Haider, Asifa S. ; Lowes, Michelle A. ; Suàrez-Fariñas, Mayte ; Zaba, Lisa C. ; Cardinale, Irma ; Blumenberg, Miroslav ; Krueger, James G. / Cellular genomic maps help dissect pathology in human skin disease. In: Journal of Investigative Dermatology. 2008 ; Vol. 128, No. 3. pp. 606-615.
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