Cellular genomic maps help dissect pathology in human skin disease

Asifa S. Haider, Michelle A. Lowes, Mayte Suàrez-Fariñas, Lisa C. Zaba, Irma Cardinale, Miroslav Blumenberg, James G. Krueger

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined "lineage-specific" genes, as well as " activation" genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps.

Original languageEnglish (US)
Pages (from-to)606-615
Number of pages10
JournalJournal of Investigative Dermatology
Volume128
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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