Cellular genomic maps help dissect pathology in human skin disease

Asifa S. Haider; Michelle A. Lowes; Mayte Suàrez-Fariñas; Lisa C. Zaba; Irma Cardinale; Miroslav Blumenberg; James G. Krueger

doi:10.1038/sj.jid.5701067

Cellular genomic maps help dissect pathology in human skin disease

Asifa S. Haider, Michelle A. Lowes, Mayte Suàrez-Fariñas, Lisa C. Zaba, Irma Cardinale, Miroslav Blumenberg, James G. Krueger

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined "lineage-specific" genes, as well as " activation" genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps.

Original language	English (US)
Pages (from-to)	606-615
Number of pages	10
Journal	Journal of Investigative Dermatology
Volume	128
Issue number	3
DOIs	https://doi.org/10.1038/sj.jid.5701067
State	Published - Mar 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.jid.5701067

Cite this

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title = "Cellular genomic maps help dissect pathology in human skin disease",

abstract = "Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined {"}lineage-specific{"} genes, as well as {"} activation{"} genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps.",

author = "Haider, {Asifa S.} and Lowes, {Michelle A.} and Mayte Su{\`a}rez-Fari{\~n}as and Zaba, {Lisa C.} and Irma Cardinale and Miroslav Blumenberg and Krueger, {James G.}",

note = "Funding Information: This research was supported in part by an NIH/Clinical and Translational Science Award (CTSA) grant UL1 RR024143. M.A.L. is supported by NIH grant K23AR052404. LCZ is supported by NIH MSTP grant GM07739. ",

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doi = "10.1038/sj.jid.5701067",

language = "English (US)",

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AU - Haider, Asifa S.

AU - Lowes, Michelle A.

AU - Suàrez-Fariñas, Mayte

AU - Zaba, Lisa C.

AU - Cardinale, Irma

AU - Blumenberg, Miroslav

AU - Krueger, James G.

N1 - Funding Information: This research was supported in part by an NIH/Clinical and Translational Science Award (CTSA) grant UL1 RR024143. M.A.L. is supported by NIH grant K23AR052404. LCZ is supported by NIH MSTP grant GM07739.

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N2 - Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined "lineage-specific" genes, as well as " activation" genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps.

AB - Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined "lineage-specific" genes, as well as " activation" genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps.

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Cellular genomic maps help dissect pathology in human skin disease

Abstract

ASJC Scopus subject areas

UN SDGs

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