Cellular basis of urothelial squamous metaplasia

Roles of lineage heterogeneity and cell replacement

Feng Xia Liang, Maarten C. Bosland, Hongying Huang, Rok Romih, Solange Baptiste, Fang Ming Deng, Xue Ru Wu, Ellen Shapiro, Tung Tien Sun

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Although the epithelial lining of much of the mammalian urinary tract is known simply as the urothelium, this epithelium can be divided into at least three lineages of renal pelvis/ureter, bladder/trigone, and proximal urethra based on their embryonic origin, uroplakin content, keratin expression pattern, in vitro growth potential, and propensity to keratinize during vitamin A deficiency. Moreover, these cells remain phenotypically distinct even after they have been serially passaged under identical culture conditions, thus ruling out local mesenchymal influence as the sole cause of their in vivo differences. During vitamin A deficiency, mouse urothelium form multiple keratinized foci in proximal urethra probably originating from scattered K14-positive basal cells, and the keratinized epithelium expands horizontally to replace the surrounding normal urothelium. These data suggest that the urothelium consists of multiple cell lineages, that trigone urothelium is closely related to the urothelium covering the rest of the bladder, and that lineage heterogeneity coupled with cell migration/replacement form the cellular basis for urothelial squamous metaplasia.

Original languageEnglish (US)
Pages (from-to)835-844
Number of pages10
JournalJournal of Cell Biology
Volume171
Issue number5
DOIs
StatePublished - Dec 5 2005
Externally publishedYes

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Urothelium
Metaplasia
Vitamin A Deficiency
Urethra
Uroplakins
Urinary Bladder
Epithelium
Kidney Pelvis
Cell Lineage
Ureter
Keratins
Urinary Tract
Cell Movement
Growth

ASJC Scopus subject areas

  • Cell Biology

Cite this

Liang, F. X., Bosland, M. C., Huang, H., Romih, R., Baptiste, S., Deng, F. M., ... Sun, T. T. (2005). Cellular basis of urothelial squamous metaplasia: Roles of lineage heterogeneity and cell replacement. Journal of Cell Biology, 171(5), 835-844. https://doi.org/10.1083/jcb.200505035

Cellular basis of urothelial squamous metaplasia : Roles of lineage heterogeneity and cell replacement. / Liang, Feng Xia; Bosland, Maarten C.; Huang, Hongying; Romih, Rok; Baptiste, Solange; Deng, Fang Ming; Wu, Xue Ru; Shapiro, Ellen; Sun, Tung Tien.

In: Journal of Cell Biology, Vol. 171, No. 5, 05.12.2005, p. 835-844.

Research output: Contribution to journalArticle

Liang, FX, Bosland, MC, Huang, H, Romih, R, Baptiste, S, Deng, FM, Wu, XR, Shapiro, E & Sun, TT 2005, 'Cellular basis of urothelial squamous metaplasia: Roles of lineage heterogeneity and cell replacement', Journal of Cell Biology, vol. 171, no. 5, pp. 835-844. https://doi.org/10.1083/jcb.200505035
Liang, Feng Xia ; Bosland, Maarten C. ; Huang, Hongying ; Romih, Rok ; Baptiste, Solange ; Deng, Fang Ming ; Wu, Xue Ru ; Shapiro, Ellen ; Sun, Tung Tien. / Cellular basis of urothelial squamous metaplasia : Roles of lineage heterogeneity and cell replacement. In: Journal of Cell Biology. 2005 ; Vol. 171, No. 5. pp. 835-844.
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