Cellular and molecular effects of trimethyltin and triethyltin

Relevance to organotin neurotoxicity

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Many of the neurotoxic aspects of organotin exposure have been described. Organotin exposure culminates in its accumulation in the CNS and PNS. The clinical picture is dominated by neurological disturbances; yet, the primary basis for their neurotoxicity is unknown. Trimethyltin (TMT) is primarily a CNS neurotoxin affecting neurons within the hippocampal pyramidal band and the fascia dentata. Triethyltin (TET) is a neurotoxin that produces a pathological picture dominated by brain and spinal cord edema. The first part of this review summarizes the current understanding of the interaction of TMT and TET with biologically active sites in the induction of neurotoxicity. In the second part, several hypotheses for the differential neurotoxic effects of these organotins and their shortcomings are discussed.

Original languageEnglish (US)
Pages (from-to)427-435
Number of pages9
JournalNeuroscience and Biobehavioral Reviews
Volume16
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Neurotoxins
Dentate Gyrus
Edema
Catalytic Domain
Spinal Cord
Neurons
Brain
trimethyltin
triethyltin

Keywords

  • Mechanisms
  • Neuroglia
  • Neurotoxicity
  • Triethyltin
  • Trimethyltin

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

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abstract = "Many of the neurotoxic aspects of organotin exposure have been described. Organotin exposure culminates in its accumulation in the CNS and PNS. The clinical picture is dominated by neurological disturbances; yet, the primary basis for their neurotoxicity is unknown. Trimethyltin (TMT) is primarily a CNS neurotoxin affecting neurons within the hippocampal pyramidal band and the fascia dentata. Triethyltin (TET) is a neurotoxin that produces a pathological picture dominated by brain and spinal cord edema. The first part of this review summarizes the current understanding of the interaction of TMT and TET with biologically active sites in the induction of neurotoxicity. In the second part, several hypotheses for the differential neurotoxic effects of these organotins and their shortcomings are discussed.",
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