TY - JOUR
T1 - Cell wall branches, penicillin resistance and the secrets of the MurM protein
AU - Fiser, András
AU - Filipe, Sergio R.
AU - Tomasz, Alexander
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2003/12
Y1 - 2003/12
N2 - Production of low-affinity forms of penicillin-binding proteins (PBPs), although essential, is not sufficient to protect pneumococci against the inhibitory action of penicillin. Resistance also requires the newly identified protein MurM which, together with MurN, is involved with the synthesis of short peptide branches in the pneumococcal cell wall. Cells in which murM was inactivated produced cell walls without branches and also completely lost penicillin resistance. To understand these surprising observations a 3D-model of MurM was constructed, which helped to put into structural context several of the biochemical and genetic observations made about this protein.
AB - Production of low-affinity forms of penicillin-binding proteins (PBPs), although essential, is not sufficient to protect pneumococci against the inhibitory action of penicillin. Resistance also requires the newly identified protein MurM which, together with MurN, is involved with the synthesis of short peptide branches in the pneumococcal cell wall. Cells in which murM was inactivated produced cell walls without branches and also completely lost penicillin resistance. To understand these surprising observations a 3D-model of MurM was constructed, which helped to put into structural context several of the biochemical and genetic observations made about this protein.
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U2 - 10.1016/j.tim.2003.10.003
DO - 10.1016/j.tim.2003.10.003
M3 - Article
C2 - 14659686
AN - SCOPUS:0344628644
SN - 0966-842X
VL - 11
SP - 547
EP - 553
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 12
ER -