Cell signaling in aging and apoptosis

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Alterations in apoptotic potential, due to perturbations in cell signaling cascades, could underlie age-related organ-specific cellular degeneration and death. While increased apoptosis could lead to cell loss, as in neuronal degeneration, loss of apoptosis competence might well result in the loss of phenotypic fidelity of somatic cells, which could explain to some extent, the age-related increase in cancer incidence. Results from our laboratory indicate that after subjecting young and old rats to genotoxic stress in the form of methyl methanesulfonate (MMS), an apoptotic response is quickly mounted in the liver of the young animals but virtually absent in the same organ of old animals (Nature Med. 8 (2002) 3). To address the possible molecular signaling defect(s) responsible for the age-related dysfunction of apoptosis in response to MMS, mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinases (ERKs), c-Jun NH2-terminal kinases (JNKs) and p38 MAPKs, were evaluated in the liver of young and old rats after MMS treatment. The results demonstrated distinct age-specific patterns of MMS-induced MAPKs activation, suggesting that the balance between cell survival and apoptosis after genotoxic stress may be impaired during aging. These results are discussed in terms of the relative importance in aging of biological redundancy, a concept put forward by the late Bernard Strehler, and cellular fidelity.

Original languageEnglish (US)
Pages (from-to)881-890
Number of pages10
JournalMechanisms of Ageing and Development
Volume123
Issue number8
DOIs
StatePublished - Apr 30 2002
Externally publishedYes

Fingerprint

Cell signaling
Methyl Methanesulfonate
Aging of materials
Apoptosis
Mitogen-Activated Protein Kinases
Liver
DNA Damage
Rats
Animals
Animal Structures
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
p38 Mitogen-Activated Protein Kinases
Mental Competency
Redundancy
Cell Survival
Chemical activation
Cells
Defects
Incidence

Keywords

  • Aging
  • Alkylating agents
  • Apoptosis
  • Cancer
  • DNA damage
  • Mitogen-activated protein kinase (MAPK)

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Cell signaling in aging and apoptosis. / Suh, Yousin.

In: Mechanisms of Ageing and Development, Vol. 123, No. 8, 30.04.2002, p. 881-890.

Research output: Contribution to journalArticle

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