Cell migration in tumors

Hideki Yamaguchi, Jeffrey Wyckoff, John S. Condeelis

Research output: Contribution to journalArticle

457 Citations (Scopus)

Abstract

Invasion of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. This requires chemotactic migration of cancer cells, steered by protrusive activity of the cell membrane and its attachment to the extracellular matrix. Recent advances in intravital imaging and the development of an in vivo invasion assay have provided new insights into how cancer cell migration is regulated by elements of the local microenvironment, including the extracellular matrix architecture and other cell types found in primary tumors. These results, combined with new findings from in vitro studies, have led to new insights into the molecular mechanisms of cell protrusive activity and chemotactic migration during invasion and metastasis.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume17
Issue number5 SPEC. ISS.
DOIs
StatePublished - Oct 2005

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Cell Movement
Neoplasms
Extracellular Matrix
Neoplasm Metastasis
Cell Membrane

ASJC Scopus subject areas

  • Cell Biology

Cite this

Cell migration in tumors. / Yamaguchi, Hideki; Wyckoff, Jeffrey; Condeelis, John S.

In: Current Opinion in Cell Biology, Vol. 17, No. 5 SPEC. ISS., 10.2005, p. 559-564.

Research output: Contribution to journalArticle

Yamaguchi, H, Wyckoff, J & Condeelis, JS 2005, 'Cell migration in tumors', Current Opinion in Cell Biology, vol. 17, no. 5 SPEC. ISS., pp. 559-564. https://doi.org/10.1016/j.ceb.2005.08.002
Yamaguchi, Hideki ; Wyckoff, Jeffrey ; Condeelis, John S. / Cell migration in tumors. In: Current Opinion in Cell Biology. 2005 ; Vol. 17, No. 5 SPEC. ISS. pp. 559-564.
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