TY - JOUR
T1 - Cell migration in tumors
AU - Yamaguchi, Hideki
AU - Wyckoff, Jeffrey
AU - Condeelis, John
N1 - Funding Information:
We apologize to those authors whose work we were unable to cite because of space and date of publication limitations. We are grateful to all laboratory members and collaborators for their support and helpful discussions. We thank M Sidani for intravital imaging pictures. This work was supported by grants from the NIH (GM38511 and CA100324).
PY - 2005/10
Y1 - 2005/10
N2 - Invasion of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. This requires chemotactic migration of cancer cells, steered by protrusive activity of the cell membrane and its attachment to the extracellular matrix. Recent advances in intravital imaging and the development of an in vivo invasion assay have provided new insights into how cancer cell migration is regulated by elements of the local microenvironment, including the extracellular matrix architecture and other cell types found in primary tumors. These results, combined with new findings from in vitro studies, have led to new insights into the molecular mechanisms of cell protrusive activity and chemotactic migration during invasion and metastasis.
AB - Invasion of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. This requires chemotactic migration of cancer cells, steered by protrusive activity of the cell membrane and its attachment to the extracellular matrix. Recent advances in intravital imaging and the development of an in vivo invasion assay have provided new insights into how cancer cell migration is regulated by elements of the local microenvironment, including the extracellular matrix architecture and other cell types found in primary tumors. These results, combined with new findings from in vitro studies, have led to new insights into the molecular mechanisms of cell protrusive activity and chemotactic migration during invasion and metastasis.
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U2 - 10.1016/j.ceb.2005.08.002
DO - 10.1016/j.ceb.2005.08.002
M3 - Review article
C2 - 16098726
AN - SCOPUS:24644445721
SN - 0955-0674
VL - 17
SP - 559
EP - 564
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 5 SPEC. ISS.
ER -
