Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye

Lihui Yang, Nicholas E. Baker

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Receptor tyrosine kinases such as the EGF receptor transduce extracellular signals into multiple cellular responses. In the developing Drosophila eye, EGFR activity triggers cell differentiation. Here we focus on three additional cell autonomous aspects of EGFR function and their coordination with differentiation, namely, withdrawal from the cell cycle, mitosis, and cell survival. We find that, whereas differentiation requires intense signaling, dependent on multiple reinforcing ligands, lesser EGFR activity maintains cell cycle arrest, promotes mitosis, and protects against cell death. Each response requires the same Ras, Raf, MAPK, and Pnt signal transduction pathway. Mitotic and survival responses also involve Pnt-independent branches, perhaps explaining how survival and mitosis can occur independently. Our results suggest that, rather than triggering all or none responses, EGFR coordinates partially independent processes as the eye differentiates.

Original languageEnglish (US)
Pages (from-to)359-369
Number of pages11
JournalDevelopmental Cell
Volume4
Issue number3
DOIs
StatePublished - Mar 1 2003

Fingerprint

Mitosis
Drosophila
Cell Survival
Cell Cycle
Cells
Signal transduction
Receptor Protein-Tyrosine Kinases
Cell death
Cell Cycle Checkpoints
Epidermal Growth Factor Receptor
Cell Differentiation
Signal Transduction
Cell Death
Ligands

ASJC Scopus subject areas

  • Developmental Biology

Cite this

@article{331a67a72a7a4359ac650051e65936bb,
title = "Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye",
abstract = "Receptor tyrosine kinases such as the EGF receptor transduce extracellular signals into multiple cellular responses. In the developing Drosophila eye, EGFR activity triggers cell differentiation. Here we focus on three additional cell autonomous aspects of EGFR function and their coordination with differentiation, namely, withdrawal from the cell cycle, mitosis, and cell survival. We find that, whereas differentiation requires intense signaling, dependent on multiple reinforcing ligands, lesser EGFR activity maintains cell cycle arrest, promotes mitosis, and protects against cell death. Each response requires the same Ras, Raf, MAPK, and Pnt signal transduction pathway. Mitotic and survival responses also involve Pnt-independent branches, perhaps explaining how survival and mitosis can occur independently. Our results suggest that, rather than triggering all or none responses, EGFR coordinates partially independent processes as the eye differentiates.",
author = "Lihui Yang and Baker, {Nicholas E.}",
year = "2003",
month = "3",
day = "1",
doi = "10.1016/S1534-5807(03)00059-5",
language = "English (US)",
volume = "4",
pages = "359--369",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye

AU - Yang, Lihui

AU - Baker, Nicholas E.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Receptor tyrosine kinases such as the EGF receptor transduce extracellular signals into multiple cellular responses. In the developing Drosophila eye, EGFR activity triggers cell differentiation. Here we focus on three additional cell autonomous aspects of EGFR function and their coordination with differentiation, namely, withdrawal from the cell cycle, mitosis, and cell survival. We find that, whereas differentiation requires intense signaling, dependent on multiple reinforcing ligands, lesser EGFR activity maintains cell cycle arrest, promotes mitosis, and protects against cell death. Each response requires the same Ras, Raf, MAPK, and Pnt signal transduction pathway. Mitotic and survival responses also involve Pnt-independent branches, perhaps explaining how survival and mitosis can occur independently. Our results suggest that, rather than triggering all or none responses, EGFR coordinates partially independent processes as the eye differentiates.

AB - Receptor tyrosine kinases such as the EGF receptor transduce extracellular signals into multiple cellular responses. In the developing Drosophila eye, EGFR activity triggers cell differentiation. Here we focus on three additional cell autonomous aspects of EGFR function and their coordination with differentiation, namely, withdrawal from the cell cycle, mitosis, and cell survival. We find that, whereas differentiation requires intense signaling, dependent on multiple reinforcing ligands, lesser EGFR activity maintains cell cycle arrest, promotes mitosis, and protects against cell death. Each response requires the same Ras, Raf, MAPK, and Pnt signal transduction pathway. Mitotic and survival responses also involve Pnt-independent branches, perhaps explaining how survival and mitosis can occur independently. Our results suggest that, rather than triggering all or none responses, EGFR coordinates partially independent processes as the eye differentiates.

UR - http://www.scopus.com/inward/record.url?scp=0037343951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037343951&partnerID=8YFLogxK

U2 - 10.1016/S1534-5807(03)00059-5

DO - 10.1016/S1534-5807(03)00059-5

M3 - Article

VL - 4

SP - 359

EP - 369

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 3

ER -