Cell cycle molecules and diseases of the cardiovascular system.

S. B. Petkova, A. Ashton, B. Bouzahzah, H. Huang, R. G. Pestell, H. B. Tanowitz

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Injury to the cardiovascular system causes an elevated expression of endothelin-1 (ET-1) and activation of several important signaling pathways including the mitogen-activated kinase (MAPK) cascade. The activation of these pathways has been implicated in the pathogenesis of cardiovascular disease caused by hypoxia, infections, and ischemia /reperfusion injury, cardiomyopathy and restenosis after balloon angioplasty. Important downstream targets of the MAPK and ET-1 pathways are the cell cycle regulatory molecules (cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors). Regulation of these molecules contributes to remodeling throughout the cardiovascular system. In addition, cell cycle molecules are important in the regulation of angiogenesis. These new data have led to the development of potential therapeutic modalities targeting these regulatory molecules in order to ameliorate various cardiovascular disease states.

Original languageEnglish (US)
Pages (from-to)D452-460
JournalFrontiers in bioscience : a journal and virtual library
Volume5
DOIs
StatePublished - Apr 1 2000

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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