Cell cycle molecules and diseases of the cardiovascular system.

S. B. Petkova, A. Ashton, B. Bouzahzah, Huan Huang, R. G. Pestell, H. B. Tanowitz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Injury to the cardiovascular system causes an elevated expression of endothelin-1 (ET-1) and activation of several important signaling pathways including the mitogen-activated kinase (MAPK) cascade. The activation of these pathways has been implicated in the pathogenesis of cardiovascular disease caused by hypoxia, infections, and ischemia /reperfusion injury, cardiomyopathy and restenosis after balloon angioplasty. Important downstream targets of the MAPK and ET-1 pathways are the cell cycle regulatory molecules (cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors). Regulation of these molecules contributes to remodeling throughout the cardiovascular system. In addition, cell cycle molecules are important in the regulation of angiogenesis. These new data have led to the development of potential therapeutic modalities targeting these regulatory molecules in order to ameliorate various cardiovascular disease states.

Original languageEnglish (US)
JournalFrontiers in Bioscience
Volume5
StatePublished - 2000

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Cardiovascular system
Cyclin-Dependent Kinases
Endothelin-1
Cardiovascular System
Cell Cycle
Cardiovascular Diseases
Cells
Molecules
Cyclins
Balloon Angioplasty
Mitogen-Activated Protein Kinase Kinases
Reperfusion Injury
Cardiomyopathies
Mitogens
Chemical activation
Balloons
Wounds and Injuries
Infection
Therapeutics
Hypoxia

Cite this

Petkova, S. B., Ashton, A., Bouzahzah, B., Huang, H., Pestell, R. G., & Tanowitz, H. B. (2000). Cell cycle molecules and diseases of the cardiovascular system. Frontiers in Bioscience, 5.

Cell cycle molecules and diseases of the cardiovascular system. / Petkova, S. B.; Ashton, A.; Bouzahzah, B.; Huang, Huan; Pestell, R. G.; Tanowitz, H. B.

In: Frontiers in Bioscience, Vol. 5, 2000.

Research output: Contribution to journalArticle

Petkova, SB, Ashton, A, Bouzahzah, B, Huang, H, Pestell, RG & Tanowitz, HB 2000, 'Cell cycle molecules and diseases of the cardiovascular system.', Frontiers in Bioscience, vol. 5.
Petkova SB, Ashton A, Bouzahzah B, Huang H, Pestell RG, Tanowitz HB. Cell cycle molecules and diseases of the cardiovascular system. Frontiers in Bioscience. 2000;5.
Petkova, S. B. ; Ashton, A. ; Bouzahzah, B. ; Huang, Huan ; Pestell, R. G. ; Tanowitz, H. B. / Cell cycle molecules and diseases of the cardiovascular system. In: Frontiers in Bioscience. 2000 ; Vol. 5.
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