TY - JOUR
T1 - Cell adhesion molecules
T2 - Signalling functions at the synapse
AU - Dalva, Matthew B.
AU - McClelland, Andrew C.
AU - Kayser, Matthew S.
N1 - Funding Information:
We thank L. Gabel for helpful comments. The authors work is supported by a Whitehall Foundation, Edward Mallinckrodt Jr Foundation, Philadelphia Foundation, and Mental Retardation Developmental Disability Research Center grant to M.B.D., the Training Program in Developmental Biology to A.C.M. and by the Ruth L. Kirschstein National Research Service Award to M.S.K.
PY - 2007/3
Y1 - 2007/3
N2 - Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide a mechanical link between cells. In this review, we will discuss the roles these proteins have during development and at mature synapses. Synaptic adhesion proteins participate in the formation, maturation, function and plasticity of synaptic connections. Together with conventional synaptic transmission mechanisms, these molecules are an important element in the trans-cellular communication mediated by synapses.
AB - Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide a mechanical link between cells. In this review, we will discuss the roles these proteins have during development and at mature synapses. Synaptic adhesion proteins participate in the formation, maturation, function and plasticity of synaptic connections. Together with conventional synaptic transmission mechanisms, these molecules are an important element in the trans-cellular communication mediated by synapses.
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U2 - 10.1038/nrn2075
DO - 10.1038/nrn2075
M3 - Review article
C2 - 17299456
AN - SCOPUS:33847119026
SN - 1471-003X
VL - 8
SP - 206
EP - 220
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 3
ER -