Celiac disease in a child with ulcerative colitis: A possible genetic association

Sam X. Cheng, Aileen Raizner, Uma P. Phatak, Judy H. Cho, Dinesh S. Pashankar

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Celiac disease and inflammatory bowel disease including ulcerative colitis (UC) and Crohn's disease are both immune-mediated enteropathies. It is rare for both celiac disease and inflammatory bowel disease to occur together in an individual patient. This association has been reported in adults, however, very rarely in children. Here, we report an unusual case of an 8-year-old child with a history of anemia and failure to thrive who presented with bloody diarrhea. His evaluation showed anemia, elevated inflammatory markers, and positive celiac antibodies. Endoscopic evaluation revealed partial duodenal villous atrophy and pancolitis. He was diagnosed with celiac disease and UC and responded well to a gluten-free diet and steroid/mesalamine therapy. The patient's genetic testing revealed markers showing susceptibility for both celiac disease and UC. It is important to be aware of this association as both conditions can present with similar clinical features, however, require different therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)127-129
Number of pages3
JournalJournal of clinical gastroenterology
Volume47
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Crohn's disease
  • celiac disease
  • ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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