Cefoperazone plus tobramycin versus ticarcillin plus tobramycin in febrile granulocytopenic cancer patients

Rasim Gucalp, Salvatore Lia, John C. McKitrick, Peter H. Wiernik

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Cefoperazone plus tobramycin was compared in a prospective, randomized trial with our standard regimen of ticarcillin plus tobramycin as empiric therapy of fever in granulocytopenic patients with cancer. Patients who received cefoperazone were also given vitamin K (5 mg orally twice a week). Of 39 microbiologically and clinically documented infections treated with ticarcillin plus tobramycin, 28 (72 percent) showed improvement. Of 27 microbiologically and clinically documented infections treated with cefoperazone plus tobramycin, 21 (78 percent) showed improvement. The overall response rates were similar (40 of 53, or 74 percent, for ticarcillin plus tobramycin versus 38 of 48, or 79 percent for cefoperazone plus tobramycin). There was no difference in response between groups according to site of infection. Serious side effects were minimal with both regimens. There were no enterococcal superinfections in patients receiving cefoperazone. These results suggest that the overall efficacy and toxicity of study regimens are similar.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
JournalThe American Journal of Medicine
Volume85
Issue number1 SUPPL. 1
DOIs
StatePublished - Jul 25 1988

ASJC Scopus subject areas

  • Medicine(all)

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