C/EBPβ is a negative regulator of human papillomavirus type 11 in keratinocytes

Hao Wang, Kai Liu, Fang Yuan, Lillian Berdichevsky, Lorne B. Taichman, Karen Auborn

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We have evaluated the impact of the CCAAT enhancer-binding protein (C/EBP) transcription factors on human papillomavirus type 11 (HPV11). C/EBPβ is in nuclei of cultured foreskin keratinocytes and hinds its consensus sequence in HPV11 DNA. We have used the novel approach of depleting the availability of C/EBPs in vivo using nuclease-resistant oligomers containing C/EBP DNA binding sites. In cultured foreskin keratinocytes containing replicating HPV11 DNA, levels of both HPV11 transcripts and HPV DNA increase after treatment with oligomers containing the C/EBPβ DNA binding motif. These results indicate that C/EBPβ is a repressor for HPV11 in keratinocytes.

Original languageEnglish (US)
Pages (from-to)4839-4844
Number of pages6
JournalJournal of Virology
Volume70
Issue number7
StatePublished - 1996
Externally publishedYes

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CCAAT-Enhancer-Binding Proteins
Human papillomavirus 11
Papillomaviridae
keratinocytes
Keratinocytes
binding proteins
Foreskin
DNA
Protein Binding
Nucleotide Motifs
DNA-binding proteins
DNA-binding domains
nucleases
consensus sequence
Consensus Sequence
binding sites
Transcription Factors
transcription factors
Binding Sites

ASJC Scopus subject areas

  • Immunology

Cite this

Wang, H., Liu, K., Yuan, F., Berdichevsky, L., Taichman, L. B., & Auborn, K. (1996). C/EBPβ is a negative regulator of human papillomavirus type 11 in keratinocytes. Journal of Virology, 70(7), 4839-4844.

C/EBPβ is a negative regulator of human papillomavirus type 11 in keratinocytes. / Wang, Hao; Liu, Kai; Yuan, Fang; Berdichevsky, Lillian; Taichman, Lorne B.; Auborn, Karen.

In: Journal of Virology, Vol. 70, No. 7, 1996, p. 4839-4844.

Research output: Contribution to journalArticle

Wang, H, Liu, K, Yuan, F, Berdichevsky, L, Taichman, LB & Auborn, K 1996, 'C/EBPβ is a negative regulator of human papillomavirus type 11 in keratinocytes', Journal of Virology, vol. 70, no. 7, pp. 4839-4844.
Wang H, Liu K, Yuan F, Berdichevsky L, Taichman LB, Auborn K. C/EBPβ is a negative regulator of human papillomavirus type 11 in keratinocytes. Journal of Virology. 1996;70(7):4839-4844.
Wang, Hao ; Liu, Kai ; Yuan, Fang ; Berdichevsky, Lillian ; Taichman, Lorne B. ; Auborn, Karen. / C/EBPβ is a negative regulator of human papillomavirus type 11 in keratinocytes. In: Journal of Virology. 1996 ; Vol. 70, No. 7. pp. 4839-4844.
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