C/EBPβ is a negative regulator of human papillomavirus type 11 in keratinocytes

Hao Wang, Kai Liu, Fang Yuan, Lillian Berdichevsky, Lorne B. Taichman, Karen Auborn

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

We have evaluated the impact of the CCAAT enhancer-binding protein (C/EBP) transcription factors on human papillomavirus type 11 (HPV11). C/EBPβ is in nuclei of cultured foreskin keratinocytes and hinds its consensus sequence in HPV11 DNA. We have used the novel approach of depleting the availability of C/EBPs in vivo using nuclease-resistant oligomers containing C/EBP DNA binding sites. In cultured foreskin keratinocytes containing replicating HPV11 DNA, levels of both HPV11 transcripts and HPV DNA increase after treatment with oligomers containing the C/EBPβ DNA binding motif. These results indicate that C/EBPβ is a repressor for HPV11 in keratinocytes.

Original languageEnglish (US)
Pages (from-to)4839-4844
Number of pages6
JournalJournal of virology
Volume70
Issue number7
Publication statusPublished - Jan 1 1996

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Wang, H., Liu, K., Yuan, F., Berdichevsky, L., Taichman, L. B., & Auborn, K. (1996). C/EBPβ is a negative regulator of human papillomavirus type 11 in keratinocytes. Journal of virology, 70(7), 4839-4844.